Ambroziak Michał, Kolanowska Monika, Bartoszewicz Zbigniew, Budaj Andrzej
Department of Cardiology, Medical Centre of Postgraduate Education, Grochowski Hospital, Grenadierów 51/59, 04-730 Warsaw, Poland.
Genomic Medicine, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland; Laboratory of Human Cancer Genetics, Centre of New Technologies, University of Warsaw, Banacha 2C, 02-097 Warsaw, Poland.
Gene. 2018 Feb 5;642:498-504. doi: 10.1016/j.gene.2017.11.064. Epub 2017 Nov 28.
The aim of the study was to investigate the role of adiponectin and 5 variants of its gene in the risk of premature myocardial infarction (MI). The studied group (MI<50) consisted of 158 young patients (125 men) aged <50 with MI. The control groups consisted of 155 healthy people (97 men), aged <50 and 202 patients (130 men) aged ≥50 with MI (MI≥50). There were statistically significant differences between MI<50 patients and healthy control group in the prevalence of rs17300539:G>A (AA genotype: 19.3% vs. 0%, p<0.0001) and rs72563731:C>T variants (CC genotype: 81.5% vs. 15.9%, p<0.0001) and between MI<50 and MI≥50 patients in variants: rs17300539:G>A (AA genotype: 19.3% vs. 0.5%, p<0.0001), rs72563731:C>T (CC genotype: 82.1% vs. 60.8%, p<0.0001), rs1501299:G>T (TT genotype: 6.8% vs. 14.9%, p=0.019) and rs822387:T>C (genotype CC: 1.5% vs. 0%, p=0.017). Multivariate analysis showed a significantly higher risk of MI in young CC carriers of rs72563731:C>T and in young AA carriers of rs17300539:G>A. Total and HMW adiponectin plasma levels have been significantly lower in MI<50 patients in comparison to MI≥50 patients (p=0.001 and p=0.001, respectively) and to healthy subjects (p=0.009 and p=0.01, respectively). Our study indicates the possible role of adiponectin and its genetic variants in MI in young age.
该研究的目的是调查脂联素及其基因的5种变体在早发心肌梗死（MI）风险中的作用。研究组（MI<50）由158名年龄<50岁的年轻心肌梗死患者（125名男性）组成。对照组包括155名年龄<50岁的健康人（97名男性）和202名年龄≥50岁的心肌梗死患者（130名男性）（MI≥50）。在rs17300539:G>A（AA基因型：19.3%对0%，p<0.0001）和rs72563731:C>T变体（CC基因型：81.5%对15.9%，p<0.0001）的患病率方面，MI<50患者与健康对照组之间存在统计学显著差异；在rs17300539:G>A（AA基因型：19.3%对0.5%，p<0.0001）、rs72563731:C>T（CC基因型：82.1%对60.8%，p<0.0001）、rs1501299:G>T（TT基因型：6.8%对14.9%，p=0.019）和rs822387:T>C（CC基因型：1.5%对0%，p=0.017）变体方面，MI<50患者与MI≥50患者之间存在统计学显著差异。多变量分析显示，rs72563731:C>T的年轻CC携带者和rs17300539:G>A的年轻AA携带者发生心肌梗死的风险显著更高。与MI≥50患者相比（分别为p=0.001和p=0.001）以及与健康受试者相比（分别为p=0.
