Norris Tom, McCarthy Fergus P, Khashan Ali S, Murray Deidre M, Kiely Mairead, Hourihane Jonathan O'B, Baker Philip N, Kenny Louise C
Department of Health Sciences, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK.
Department of Obstetrics and Gynecology, The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork, Ireland.
BMJ Open. 2017 Dec 1;7(11):e017987. doi: 10.1136/bmjopen-2017-017987.
To investigate whether changing levels of exercise during pregnancy are related to altered neonatal adiposity.
Secondary analysis of data from a prospective cohort study.
Cork, Ireland.
1200 mother infant pairs recruited as part of a prospective birth cohort, Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints (BASELINE).
Neonatal adiposity was assessed within several days of birth using air displacement plethysmography (PEAPOD). Per cent body fat (BF%) as a continuous outcome and a pair of dichotomous variables; high or low adiposity, representing BF% >90th or <10th centile, respectively. Multivariable linear and logistic regression models were used to investigate the relationship between exercise and the respective outcomes.
Crude analysis revealed no association between a changing level of exercise (since becoming pregnant) at 15 weeks' gestation and any of the outcomes (BF%, low adiposity and high adiposity). At 20 weeks' gestation, analyses revealed that relative to women who do not change their exercise level up to 20 weeks, those women who decreased their exercise level were more likely to give birth to a neonate with adiposity above the 90th centile (OR 1.62, 95% CI 1.07 to 2.46). This association was maintained after adjustment for putative confounders (OR 1.62, 95% CI 1.06 to 2.47).
We observed a possible critical period for the association between changing exercise levels and neonatal adiposity, with no association observed with exercise recall for the first 15 weeks of gestation, but an association with a decreasing level of exercise between 15 and 20 weeks. These results should be interpreted in line with the limitations of the study and further studies utilising objectively measured estimates of exercise are required in order to replicate these findings.
NCT01498965.
研究孕期运动水平的变化是否与新生儿肥胖的改变有关。
对一项前瞻性队列研究的数据进行二次分析。
爱尔兰科克。
1200对母婴，作为前瞻性出生队列“婴儿SCOPE研究：使用神经和营养终点评估纵向影响”（BASELINE）的一部分招募。
出生后数天内使用空气置换体积描记法（PEAPOD）评估新生儿肥胖。体脂百分比（BF%）作为连续变量以及一对二分变量；高肥胖或低肥胖，分别代表BF%>第90百分位数或<第10百分位数。使用多变量线性和逻辑回归模型研究运动与各自结果之间的关系。
粗分析显示，妊娠15周时运动水平的变化（自怀孕以来）与任何结果（BF%、低肥胖和高肥胖）之间均无关联。在妊娠20周时，分析显示，与在20周前不改变运动水平的女性相比，运动水平下降的女性更有可能生出肥胖高于第90百分位数的新生儿（比值比1.62，95%置信区间1.07至2.46）。在对假定的混杂因素进行调整后，这种关联仍然存在（比值比1.62，95%置信区间1.06至2.47）。
我们观察到运动水平变化与新生儿肥胖之间的关联可能存在一个关键时期，妊娠前15周的运动回忆与肥胖无关联，但妊娠15至20周期间运动水平下降与肥胖有关联。这些结果应结合研究的局限性进行解释，并且需要进一步的研究利用客观测量的运动估计值来重复这些发现。
NCT01498965。
