Medical Imaging Center, Nanfang Hospital, ‡Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, and §School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, People's Republic of China.
ACS Appl Mater Interfaces. 2017 Dec 27;9(51):44316-44323. doi: 10.1021/acsami.7b15052. Epub 2017 Dec 12.
Optical/MRI bimodal probes have attracted much attention due to palmary soft tissue resolution and high imaging sensitivity. In this study, poly[fluorene-co-alt-p-phenylene] containing organic radical (PFP-TEMPO+) is successfully developed for optical and MRI dual-modality bioimaging. PFP-TEMPO+ displays advanced properties such as fluorescence emission, high photostablilty, reasonable T relaxation effect, low cytotoxicity, and good biocompatibility. Moreover, the ability of PFP-TEMPO+ for tumor tissues imaging confirms that it could be used as an optical and MRI imaging probe for in vivo imaging. The results of the present work disclose the potential applications of PFP-TEMPO+ as an optical and MRI contrast agent.
由于具有出色的软组织分辨率和高成像灵敏度，光学/MRI 双模探针引起了广泛关注。在这项研究中，成功开发了含有有机自由基（PFP-TEMPO+）的聚[芴-co--alt-对苯撑]用于光学和 MRI 双模式生物成像。PFP-TEMPO+ 具有荧光发射、高稳定性、合理的 T1 弛豫效应、低细胞毒性和良好的生物相容性等先进性能。此外，PFP-TEMPO+ 对肿瘤组织成像的能力证实，它可用作体内成像的光学和 MRI 成像探针。本工作的结果揭示了 PFP-TEMPO+作为光学和 MRI 造影剂的潜在应用。
