Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Curr Opin Clin Nutr Metab Care. 2018 Mar;21(2):138-144. doi: 10.1097/MCO.0000000000000444.
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with a high prevalence of extrapulmonary manifestations and, frequently, cardiovascular comorbidity. Resveratrol is a food-derived compound with anti-inflammatory, antioxidant, metabolic and cardioprotective potential. Therefore, resveratrol might improve the pulmonary as well as extrapulmonary pathology in COPD. In this review, we will evaluate knowledge on the effects of resveratrol on lung injury, muscle metabolism and cardiovascular risk profile and discuss if resveratrol is a hype or hope for patients with COPD.
Experimental models of COPD consistently show decreased inflammation and oxidative stress in the lungs after resveratrol treatment. These beneficial anti-inflammatory and antioxidant properties of resveratrol can indirectly also improve both skeletal and respiratory muscle impairment in COPD. Recent clinical studies in non-COPD populations show improved mitochondrial oxidative metabolism after resveratrol treatment, which could be beneficial for both lung and muscle impairment in COPD. Moreover, preclinical studies suggest cardioprotective effects of resveratrol but results of clinical studies are inconclusive.
Resveratrol might be an interesting therapeutic candidate to counteract lung and muscle impairments characteristic to COPD. However, there is no convincing evidence that resveratrol will significantly decrease the cardiovascular risk in patients with COPD.
慢性阻塞性肺疾病（COPD）是一种进展性肺部疾病，具有较高的肺外表现发生率，并且常伴有心血管合并症。白藜芦醇是一种具有抗炎、抗氧化、代谢和心脏保护作用的食物衍生化合物。因此，白藜芦醇可能改善 COPD 患者的肺部和肺外病理。在这篇综述中，我们将评估白藜芦醇对肺损伤、肌肉代谢和心血管风险特征的影响，并讨论白藜芦醇是否是 COPD 患者的炒作还是希望。
COPD 的实验模型一致显示，白藜芦醇治疗后肺部炎症和氧化应激减轻。白藜芦醇的这些有益的抗炎和抗氧化特性也可以间接改善 COPD 中的骨骼肌和呼吸肌损伤。最近在非 COPD 人群中的临床研究表明，白藜芦醇治疗后线粒体氧化代谢得到改善，这对 COPD 中的肺和肌肉损伤都有益。此外，临床前研究表明白藜芦醇具有心脏保护作用，但临床研究结果尚无定论。
白藜芦醇可能是一种有前途的治疗候选药物，可对抗 COPD 特有的肺和肌肉损伤。然而，尚无令人信服的证据表明白藜芦醇会显著降低 COPD 患者的心血管风险。
