Kumar Mitesh, Sidana Ajeet
Department of Psychiatry, Government Medical College and Hospital, Chandigarh, India.
Indian J Psychol Med. 2017 Sep-Oct;39(5):682-684. doi: 10.4103/0253-7176.217031.
The aim of this study is to highlight the association between the use of clozapine and the early development of hypertriglyceridemia, a condition that substantially increases the risk of cardiovascular events and other medical complications. A 34-year-old female with a background history of schizophrenia presented with acute elevation of serum triglycerides and cholesterol within 2 weeks of starting clozapine. Her metabolic parameters normalized following discontinuation of clozapine. Possible hypotheses for lipid dysregulation with atypical antipsychotics include weight gain, dietary changes, and development of glucose intolerance; however, some other factors may be responsible for this rapid escalation of lipid levels. Lipid and metabolic profiles should be closely monitored in patients receiving clozapine to facilitate early detection and intervention to prevent further health complications.
本研究的目的是强调使用氯氮平与高甘油三酯血症早期发展之间的关联，高甘油三酯血症会大幅增加心血管事件和其他医学并发症的风险。一名有精神分裂症病史的34岁女性在开始使用氯氮平后2周内出现血清甘油三酯和胆固醇急性升高。停用氯氮平后，她的代谢参数恢复正常。非典型抗精神病药物导致脂质失调的可能假说包括体重增加、饮食变化和葡萄糖不耐受的发展；然而，其他一些因素可能是脂质水平迅速升高的原因。接受氯氮平治疗的患者应密切监测脂质和代谢情况，以便早期发现并进行干预，预防进一步的健康并发症。
