• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用苯基异氰酸酯衍生化后，通过液相色谱 - 串联质谱法（电喷雾电离）测定十二醇和短链乙氧基化十二醇。

Determination of Dodecanol and Short-Chained Ethoxylated Dodecanols by LC-MS/MS (with Electrospray Ionization) After Their Derivatization (with Phenyl Isocyanate).

作者信息

Zembrzuska Joanna

机构信息

Institute of Chemistry and Technical Electrochemistry, Poznan University of Technology, Berdychowo 4, 60-965 Poznan, Poland.

出版信息

J Surfactants Deterg. 2017;20(6):1421-1432. doi: 10.1007/s11743-017-2015-z. Epub 2017 Sep 9.

DOI:10.1007/s11743-017-2015-z
PMID:29200813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5686276/
Abstract

ABSTRACT

This report describes the application of LC-MS/MS for the separation of dodecanol (COH) and homogenous fatty alcohols ethoxylated (AE) containing a dodecyl moiety and 1-9 ethoxy groups. These ethoxylates and free alcohol were derivatized for LC-MS/MS analysis with phenyl isocyanate (PIC). The derivatives of analytes with PIC were separated using a C18 column. Gradient elution with a mixture of ethyl acetate and acetonitrile (5 mM) was employed. The described determination method is characterized by low detection limits (range from 0.005 µg L for: COH, CEO to 1 µg L for CEO) and quantification limits (range from 0.01 µg L for: CEO to 2 µg L for CEO). The developed and validated method was used in combination with liquid-liquid extraction (using ethyl acetate) in order to identify and quantitatively determine the COH and CEO present in environmental samples collected from Warta river water in Poznan.

摘要

摘要

本报告描述了液相色谱-串联质谱法（LC-MS/MS）在分离十二醇（COH）以及含有十二烷基部分和1至9个乙氧基的均相脂肪醇乙氧基化物（AE）方面的应用。这些乙氧基化物和游离醇用异氰酸苯酯（PIC）进行衍生化，用于LC-MS/MS分析。使用C18柱分离分析物与PIC的衍生物。采用乙酸乙酯和乙腈（5 mM）混合物进行梯度洗脱。所描述的测定方法的特点是检测限低（COH、CEO为0.005 μg/L，CEO为1 μg/L）和定量限低（CEO为0.01 μg/L，CEO为2 μg/L）。所开发并经过验证的方法与液-液萃取（使用乙酸乙酯）相结合，用于鉴定和定量测定从波兹南瓦尔塔河水中采集的环境样品中存在的COH和CEO。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c24/5686276/f6b47f1f0054/11743_2017_2015_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c24/5686276/32687d9d302c/11743_2017_2015_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c24/5686276/19066f113422/11743_2017_2015_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c24/5686276/26a7772c5072/11743_2017_2015_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c24/5686276/76c7f0b32856/11743_2017_2015_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c24/5686276/c194a29a5eff/11743_2017_2015_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c24/5686276/f6b47f1f0054/11743_2017_2015_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c24/5686276/32687d9d302c/11743_2017_2015_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c24/5686276/19066f113422/11743_2017_2015_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c24/5686276/26a7772c5072/11743_2017_2015_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c24/5686276/76c7f0b32856/11743_2017_2015_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c24/5686276/c194a29a5eff/11743_2017_2015_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c24/5686276/f6b47f1f0054/11743_2017_2015_Fig6_HTML.jpg

相似文献

1
Determination of Dodecanol and Short-Chained Ethoxylated Dodecanols by LC-MS/MS (with Electrospray Ionization) After Their Derivatization (with Phenyl Isocyanate).用苯基异氰酸酯衍生化后，通过液相色谱 - 串联质谱法（电喷雾电离）测定十二醇和短链乙氧基化十二醇。
J Surfactants Deterg. 2017;20(6):1421-1432. doi: 10.1007/s11743-017-2015-z. Epub 2017 Sep 9.
2
Monitoring of selected non-ionic surfactants in river water by liquid chromatography-tandem mass spectrometry.采用液相色谱-串联质谱法监测河水中选定的非离子表面活性剂。
J Environ Manage. 2016 Mar 15;169:247-52. doi: 10.1016/j.jenvman.2015.12.034. Epub 2016 Jan 12.
3
Isocyanate derivatization coupled with phospholipid removal microelution-solid phase extraction for the simultaneous quantification of (S)-metoprolol and (S)-α-hydroxymetoprolol in human plasma with LC-MS/MS.异氰酸酯衍生化结合磷脂去除微萃取-固相萃取法，用于 LC-MS/MS 同时测定人血浆中（S）-美托洛尔和（S）-α-羟美托洛尔的浓度。
J Pharm Biomed Anal. 2021 Sep 10;204:114263. doi: 10.1016/j.jpba.2021.114263. Epub 2021 Jul 13.
4
Chromium(VI) oxide oxidation of non-ethoxylated and ethoxylated alcohols for determination by electrospray ionization mass spectrometry.采用电喷雾电离质谱法测定非乙氧基化和乙氧基化醇的六价铬氧化物氧化。
Rapid Commun Mass Spectrom. 2010 Jul 30;24(14):2093-100. doi: 10.1002/rcm.4624.
5
Determination of dodecanol and ethoxylated fatty alcohols from environmental samples using diatomaceous earth as a green sorbent for solid-phase extraction.采用硅藻土作为绿色吸附剂固相萃取环境样品中的十二醇和乙氧基化脂肪醇。
J Sep Sci. 2019 Mar;42(5):1019-1026. doi: 10.1002/jssc.201800940. Epub 2019 Jan 7.
6
Analysis of aminoglycoside residues in bovine milk by liquid chromatography electrospray ion trap mass spectrometry after derivatization with phenyl isocyanate.异氰酸苯酯衍生化后用液相色谱-电喷雾离子阱质谱法分析牛乳中的氨基糖苷类残留
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 15;877(14-15):1487-93. doi: 10.1016/j.jchromb.2009.03.025. Epub 2009 Mar 24.
7
Single-pump bi-dimensional LC applied to the characterization of derivatized fatty alcohol ethoxylates.单泵二维 LC 用于衍生脂肪醇乙氧基化物的表征。
J Sep Sci. 2010 Jun;33(10):1398-404. doi: 10.1002/jssc.200900723.
8
Development and validation of an LC-ESI/MS/MS method with precolumn derivatization for the determination of betulin in rat plasma.建立并验证了一种采用柱前衍生化的 LC-ESI/MS/MS 方法，用于大鼠血浆中白桦脂醇的定量分析。
J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Nov 15;939:38-44. doi: 10.1016/j.jchromb.2013.09.005. Epub 2013 Sep 10.
9
Parallel pathways of ethoxylated alcohol biodegradation under aerobic conditions.有氧条件下乙氧基化醇生物降解的平行途径。
Sci Total Environ. 2016 Jul 1;557-558:612-9. doi: 10.1016/j.scitotenv.2016.03.112. Epub 2016 Mar 31.
10
[Determination of eight environmental phenols in human urine samples by high-throughput solid-phase extraction-ultra-performance liquid chromatography-tandem mass spectrometry].[采用高通量固相萃取-超高效液相色谱-串联质谱法测定人尿液样本中的8种环境酚类物质]
Se Pu. 2020 Dec 8;38(12):1456-1464. doi: 10.3724/SP.J.1123.2020.07021.

引用本文的文献

1
Metabolism of alcohol ethoxylates (AEs) in rat, hamster, and human hepatocytes and liver S9: a pilot study for metabolic stability, metabolic pathway, and metabolites identification in vitro and in silico.在大鼠、仓鼠和人肝细胞及肝 S9 中的醇醚（AE）代谢：体外和计算的代谢稳定性、代谢途径和代谢物鉴定的初步研究。
Arch Toxicol. 2024 Aug;98(8):2487-2539. doi: 10.1007/s00204-024-03761-y. Epub 2024 Jun 6.

本文引用的文献

1
Determination of the four major surfactant classes in cleaning products by reversed-phase liquid chromatography using serially connected UV and evaporative light-scattering detection.使用串联紫外和蒸发光散射检测的反相液相色谱法测定清洁产品中的四大类表面活性剂。
Anal Chim Acta. 2016 Aug 17;932:106-13. doi: 10.1016/j.aca.2016.05.022. Epub 2016 May 24.
2
Parallel pathways of ethoxylated alcohol biodegradation under aerobic conditions.有氧条件下乙氧基化醇生物降解的平行途径。
Sci Total Environ. 2016 Jul 1;557-558:612-9. doi: 10.1016/j.scitotenv.2016.03.112. Epub 2016 Mar 31.
3
Monitoring of selected non-ionic surfactants in river water by liquid chromatography-tandem mass spectrometry.
采用液相色谱-串联质谱法监测河水中选定的非离子表面活性剂。
J Environ Manage. 2016 Mar 15;169:247-52. doi: 10.1016/j.jenvman.2015.12.034. Epub 2016 Jan 12.
4
Comprehensive analysis of fatty alcohol ethoxylates by ultra high pressure hydrophilic interaction chromatography coupled with ion mobility spectrometry mass spectrometry using a custom-designed sub-2 μm column.使用定制设计的亚 2μm 柱，通过超高压亲水相互作用色谱与离子淌度质谱联用对脂肪醇聚氧乙烯醚进行综合分析。
J Sep Sci. 2015 Jun;38(12):2182-91. doi: 10.1002/jssc.201500185. Epub 2015 May 13.
5
Separation and determination of homogenous fatty alcohol ethoxylates by liquid chromatography with mulitstage mass spectrometry.采用液相色谱-多级质谱联用技术分离和测定均相脂肪醇聚氧乙烯醚
J Sep Sci. 2014 Jul;37(13):1694-702. doi: 10.1002/jssc.201301391. Epub 2014 May 15.
6
Derivatization of hydroxyl functional groups for liquid chromatography and capillary electroseparation.羟基官能团的衍生化用于液相色谱和毛细管电泳分离。
J Chromatogr A. 2013 Jun 28;1296:140-56. doi: 10.1016/j.chroma.2013.04.027. Epub 2013 Apr 17.
7
Solid-phase extraction combined with dispersive liquid-liquid microextraction, fast derivatisation and high performance liquid chromatography-tandem mass spectrometry analysis for trace determination of short-chained dodecyl alcohol ethoxylates and dodecyl alcohol in environmental water samples.固相萃取结合分散液液微萃取、快速衍生化和高效液相色谱-串联质谱分析测定环境水样中短链十二醇聚氧乙烯醚和十二醇的痕量。
J Chromatogr A. 2012 Aug 17;1251:40-47. doi: 10.1016/j.chroma.2012.06.056. Epub 2012 Jun 26.
8
Environmental analysis of alcohol ethoxylates and nonylphenol ethoxylate metabolites by ultra-performance liquid chromatography-tandem mass spectrometry.采用超高效液相色谱-串联质谱法对醇聚氧乙烯醚和壬基酚聚氧乙烯醚代谢物进行环境分析。
Anal Bioanal Chem. 2012 Mar;402(7):2359-68. doi: 10.1007/s00216-011-5449-6. Epub 2011 Oct 15.
9
Separation of nonionic surfactants by capillary electrophoresis and high-performance liquid chromatography.
Anal Chem. 1998 May 1;70(9):1885-92. doi: 10.1021/ac9709155.
10
Determination of non-ionic and anionic surfactants in environmental water matrices.环境水样中非离子和阴离子表面活性剂的测定。
Talanta. 2011 May 15;84(3):859-66. doi: 10.1016/j.talanta.2011.02.009. Epub 2011 Feb 25.