苯海索（安坦）过量后的系列血清药物浓度及延长的抗胆碱能毒性

Serial serum drug concentrations and prolonged anticholinergic toxicity after benztropine (Cogentin) overdose.

作者信息

Fahy P, Arnold P, Curry S C, Bond R

机构信息

Department of Medicine, Good Samaritan Medical Center, Phoenix, AZ.

出版信息

Am J Emerg Med. 1989 Mar;7(2):199-202. doi: 10.1016/0735-6757(89)90139-3.

DOI:10.1016/0735-6757(89)90139-3

PMID:2920086

Abstract

A 38-year-old man overdosed on benztropine mesylate (Cogentin; Merck Sharpe & Dohme, West Point, PA) and developed anticholinergic poisoning syndrome, which lasted nine days. Serial serum benztropine concentrations were obtained during his hospitalization. Fluctuating benztropine levels suggested that his lengthy intoxication may have been secondary to prolonged, intermittent absorption rather than from slow plasma clearance. This is believed to be the first report of serial serum benztropine concentrations after overdose.

摘要

一名38岁男子过量服用甲磺酸苯扎托品（安坦；默克夏普&多贺美公司，宾夕法尼亚州西点），并出现抗胆碱能中毒综合征，该综合征持续了九天。在他住院期间测定了一系列血清苯扎托品浓度。苯扎托品水平波动表明，他长时间中毒可能是由于长时间、间歇性吸收，而非血浆清除缓慢所致。据信，这是过量服用后一系列血清苯扎托品浓度的首例报告。