Howrie D L, Rowley A H, Krenzelok E P
Ann Emerg Med. 1986 May;15(5):594-6. doi: 10.1016/s0196-0644(86)81001-0.
We report an unusual case of benztropine-induced acute dystonia and dyskinesia without findings of acute anticholinergic toxicity in a 20-month-old child. Laboratory analysis of blood, urine, and gastric contents demonstrated the presence of an atropinic compound and diphenhydramine only, suggesting the association of benztropine and acute dystonia. Effects of benztropine on neuronal uptake of dopamine may represent a possible mechanism for this unusual adverse effect.
我们报告了一例20个月大儿童使用苯海索后出现急性肌张力障碍和运动障碍的罕见病例，未发现急性抗胆碱能毒性表现。血液、尿液和胃内容物的实验室分析仅显示存在一种阿托品化合物和苯海拉明，提示苯海索与急性肌张力障碍之间存在关联。苯海索对多巴胺神经元摄取的影响可能是这种罕见不良反应的一种潜在机制。
