意大利南部职业暴露导致的淋巴瘤亚型风险。
Risk of lymphoma subtypes by occupational exposure in Southern Italy.
作者信息
Ferri Giovanni Maria, Specchia Giorgina, Mazza Patrizio, Ingravallo Giuseppe, Intranuovo Graziana, Guastadisegno Chiara Monica, Congedo Maria Luisa, Lagioia Gianfranco, Loparco Maria Cristina, Giordano Annamaria, Perrone Tommasina, Gaudio Francesco, Spinosa Caterina, Minoia Carla, D'Onghia Lucia, Strusi Michela, Corrado Vincenzo, Cavone Domenica, Vimercati Luigi, Schiavulli Nunzia, Cocco Pierluigi
机构信息
Department of Interdisciplinary Medicine (DIM), Section "B. Ramazzini", Regional University Hospital "Policlinico - Giovanni XXIII°", Unit of Occupational Medicine, University of Bari, Piazza G. Cesare, 11, 70124 Bari, Italy.
Interdisciplinary Department of Medicine (DIM), University Hospital. Policlinico-Giovanni XXIII, University of Bari, Piazza Giulio Cesare, 11, 70124 Bari, Italy.
出版信息
J Occup Med Toxicol. 2017 Nov 23;12:31. doi: 10.1186/s12995-017-0177-2. eCollection 2017.
BACKGROUND
Occupational exposure is known to play a role in the aetiology of lymphomas. The aim of the present work was to explore the occupational risk of the major B-cell lymphoma subtypes using a case-control study design.
METHODS
From 2009 to 2014, we recruited 158 lymphoma cases and 76 controls in the provinces of Bari and Taranto (Apulia, Southern Italy). A retrospective assessment of occupational exposure based on complete work histories and the Carcinogen Exposure (CAREX) job-exposure matrix was performed.
RESULTS
After adjusting for major confounding factors, farmers showed an increased risk of diffuse large B-cell lymphoma (DLBCL) [odds ratio (OR) = 10.9 (2.3-51.6)] and multiple myeloma (MM) [OR = 16.5 (1.4-195.7)]; exposure to the fungicide Captafol was significantly associated with risk of non-Hodgkin lymphoma (NHL) [OR = 2.6 (1.1-8.2)], particularly with the risk of DLBCL [OR = 5.3 (1.6-17.3)].
CONCLUSIONS
Agricultural activity seems to be a risk factor for developing lymphoma subtypes, particularly DLBCL, in the provinces of Bari and Taranto (Apulia Region, Southern Italy). Exposure to the pesticides Captafol, Paraquat and Radon might be implicated.
TRIAL REGISTRATION
Protocol number UNIBA 2207WEJLZB_004 registered 22/09/2008.
背景
职业暴露在淋巴瘤病因学中起着一定作用。本研究旨在采用病例对照研究设计，探讨主要B细胞淋巴瘤亚型的职业风险。
方法
2009年至2014年，我们在巴里省和塔兰托省（意大利南部普利亚大区）招募了158例淋巴瘤病例和76名对照。基于完整工作经历和致癌物暴露（CAREX）职业暴露矩阵对职业暴露进行回顾性评估。
结果
在对主要混杂因素进行调整后，农民患弥漫性大B细胞淋巴瘤（DLBCL）的风险增加[比值比（OR）=10.9（2.3 - 51.6）]，患多发性骨髓瘤（MM）的风险增加[OR = 16.5（1.4 - 195.7）]；接触杀真菌剂克菌丹与非霍奇金淋巴瘤（NHL）风险显著相关[OR = 2.6（1.1 - 8.2）]，尤其是与DLBCL风险相关[OR = 5.3（1.6 - 17.3）]。
结论
在巴里省和塔兰托省（意大利南部普利亚大区），农业活动似乎是淋巴瘤亚型，特别是DLBCL发病的危险因素。接触农药克菌丹、百草枯和氡可能与之有关。
试验注册
协议编号UNIBA 2207WEJLZB_004，于2008年9月22日注册。
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