Li Wei, Li Ning, Sui Bing, Yang Daping
Department of Plastic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
Exp Ther Med. 2017 Nov;14(5):5045-5050. doi: 10.3892/etm.2017.5163. Epub 2017 Sep 21.
Fullerenol is similar to graphite in terms of structure. In the present study, the anti-aging effect of fullerenol on skin through derived stem cells in a mouse model was assessed and the potential mechanism of fullerenol was investigated. The anti-aging effect of fullerenol effectively inhibited the retention rate of transplanted adipose-derived stem cells and increased the thickness of the dermal portion of skin and collagen ratio in mice. The effect of fullerenol on the proliferation of stem cells was observed. Treatment with fullerenol effectively promoted the mRNA expression of Runt-related transcription factor 2, alkaline phosphatase and osteocalcin in a mouse model of skin aging induced by D-galactose. However, fullerenol treatment effectively suppressed the protein expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) and increased forkhead box protein O1 (FoxO1) protein expression in the mice model of skin aging induced by D-galactose. These results demonstrate that the anti-aging effect of fullerenol on skin through derived stem cells may be mediated in mice via the PPAR-γ/FoxO1 signaling pathway.
富勒醇在结构上与石墨相似。在本研究中，评估了富勒醇通过小鼠模型中的衍生干细胞对皮肤的抗衰老作用，并研究了富勒醇的潜在作用机制。富勒醇的抗衰老作用有效抑制了移植的脂肪来源干细胞的保留率，并增加了小鼠皮肤真皮层的厚度和胶原蛋白比例。观察了富勒醇对干细胞增殖的影响。在D-半乳糖诱导的皮肤衰老小鼠模型中，富勒醇处理有效促进了与Runt相关的转录因子2、碱性磷酸酶和骨钙素的mRNA表达。然而，在D-半乳糖诱导的皮肤衰老小鼠模型中，富勒醇处理有效抑制了过氧化物酶体增殖物激活受体-γ（PPAR-γ）的蛋白表达，并增加了叉头框蛋白O1（FoxO1）的蛋白表达。这些结果表明，富勒醇通过衍生干细胞对皮肤的抗衰老作用在小鼠中可能通过PPAR-γ/FoxO1信号通路介导。
