Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, via Salvatore Allende, 84081 Baronissi, Italy.
Dipartimento di Scienze Biomediche Avanzate, Università Federico II di Napoli, via Pansini 5, 80131 Napoli, Italy.
Oxid Med Cell Longev. 2017;2017:1089359. doi: 10.1155/2017/1089359. Epub 2017 Oct 22.
The discovery of the molecular mechanisms involved in the cardiac responses to anticancer drugs represents the current goal of cardio-oncology research. The oxidative stress has a pivotal role in cardiotoxic responses, affecting the function of all types of cardiac cells, and their functional crosstalks. Generally, cardiomyocytes are the main target of research studies on cardiotoxicity, but recently the contribution of the other nonmyocyte cardiac cells is becoming of growing interest. This review deals with the role of oxidative stress, induced by anticancer drugs, in cardiac nonmyocyte cells (fibroblasts, vascular cells, and immune cells). The alterations of functional interplays among these cardiac cells are discussed, as well. These interesting recent findings increase the knowledge about cardiotoxicity and suggest new molecular targets for both diagnosis and therapy.
涉及抗癌药物引起的心脏反应的分子机制的发现，是当前心血管肿瘤学研究的目标。氧化应激在心脏毒性反应中起着关键作用，影响所有类型的心肌细胞及其功能串扰。一般来说，心肌细胞是心脏毒性研究的主要目标，但最近，其他非心肌细胞在心脏中的作用正引起越来越多的关注。这篇综述讨论了抗癌药物引起的氧化应激在心脏非心肌细胞（成纤维细胞、血管细胞和免疫细胞）中的作用。还讨论了这些心脏细胞之间功能相互作用的改变。这些有趣的最新发现增加了对心脏毒性的认识，并为诊断和治疗提供了新的分子靶点。
