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AC化疗方案的三个周期增加了乳腺癌患者的氧化应激：一项临床提示。

Three cycles of AC chemotherapy regimen increased oxidative stress in breast cancer patients: A clinical hint.

作者信息

Taherkhani Mostafa, Mahjoub Soleiman, Moslemi Dariush, Karkhah Ahmad

机构信息

Student Research Committee, Babol University of Medical Sciences, Babol, Iran.

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

出版信息

Caspian J Intern Med. 2017 Fall;8(4):264-268. doi: 10.22088/cjim.8.4.264.

DOI:10.22088/cjim.8.4.264
PMID:29201316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5686304/
Abstract

BACKGROUND

Recent studies have suggested the importance of oxidant/antioxidant status in initiation and progression of breast cancer. The aim of this study was to evaluate oxidative stress markers in breast cancer patients before and after 3 cycles of chemotherapy with adriamycin and cytoxan (AC). Also, in this study the effect of age and the stage of disease on oxidative stress markers were compared and evaluated.

METHODS

This study included 60 women with newly diagnosed stage II-III breast cancer who underwent chemotherapy with AC as the therapy-first strategy after surgery. Serum samples were obtained before treatment and after the third chemotherapy. Then, serum total antioxidant status (TAS) and malondialdehyde (MDA) as lipid peroxidation marker were analyzed. Moreover, the effects of the subject's age and clinical disease stage were investigated.

RESULTS

A concurrent significant increase in MDA (p<0.001) and a significant decrease in TAS (p<0.001) were also observed after 3 cycles of AC chemotherapy. In addition, some changes were found in the status of oxidative stress markers which were associated with age and clinical disease stage.

CONCLUSION

Our data indicated that chemotherapy with AC increase the oxidative stress in breast cancer patients. The present study indicated that higher stages of the breast cancer are associated with significant increases of oxidative stress markers.

摘要

背景

近期研究表明氧化/抗氧化状态在乳腺癌的发生和发展中具有重要意义。本研究旨在评估乳腺癌患者在接受3个周期的阿霉素和环磷酰胺（AC）化疗前后的氧化应激标志物。此外，本研究还比较并评估了年龄和疾病分期对氧化应激标志物的影响。

方法

本研究纳入了60例新诊断为II - III期乳腺癌的女性患者，她们在手术后接受AC化疗作为首选治疗策略。在治疗前和第三次化疗后采集血清样本。然后，分析血清总抗氧化状态（TAS）和作为脂质过氧化标志物的丙二醛（MDA）。此外，还研究了受试者年龄和临床疾病分期的影响。

结果

在3个周期的AC化疗后，还观察到MDA同时显著增加（p<0.001）和TAS显著降低（p<0.001）。此外，在氧化应激标志物状态方面发现了一些与年龄和临床疾病分期相关的变化。

结论

我们的数据表明，AC化疗会增加乳腺癌患者的氧化应激。本研究表明，乳腺癌的更高分期与氧化应激标志物的显著增加有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4259/5686304/a23131797934/cjim-8-264-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4259/5686304/11d20d047521/cjim-8-264-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4259/5686304/a23131797934/cjim-8-264-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4259/5686304/11d20d047521/cjim-8-264-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4259/5686304/a23131797934/cjim-8-264-g002.jpg

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