乌干达坎帕拉采用B+方案的HIV阳性母亲所生婴儿中HIV的早期诊断
Early Diagnosis of HIV among Infants Born to HIV-Positive Mothers on Option-B Plus in Kampala, Uganda.
作者信息
Izudi Jonathan, Auma Sylvia, Alege John Bosco
机构信息
Department of Community Health, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Institute of Public Health and Management, International Health Sciences University, Kampala, Uganda.
出版信息
AIDS Res Treat. 2017;2017:4654763. doi: 10.1155/2017/4654763. Epub 2017 Oct 19.
INTRODUCTION
Globally, there is delay in accessing early HIV diagnosis (EID) among HIV exposed infants (HEIs). With paucity of data on EID use at Kisenyi Health Center, this study assessed factors associated with EID use among HEIs (HIV exposed infants).
METHOD
This was a cross-sectional study of 246 HIV-positive mother-baby pairs. Data was collected by structured questionnaire, double-entered in EpiData, and analyzed with STATA using multinomial logistic regression at 5% significance level.
RESULTS
132 (53.7%) HEIs were not tested, 60 (24.4%) tested outside EID guideline, and 54 (21.9%) tested per the guideline. Testing per guideline was associated with maternal age above 30 years (AOR = 2.75; 95% CI: 1.20-6.34; = 0.017); testing outside the guideline was associated with maternal HIV serostatus disclosure (AOR = 2.70; 95% CI: 1.10-6.63; = 0.003) and four or more antenatal care (ANC) visits (AOR = 3.25; 95% CI: 1.23-8.59; = 0.017). However, maternal knowledge of HIV transmission was associated with testing outside the guideline (AOR = 2.90; 95% CI: 1.10-7.65; = 0.032) and per the guideline (AOR = 3.70; 95% CI: 1.39-9.88; = 0.009).
CONCLUSION
Timely EID testing was low. Improving maternal knowledge of EID during ANC visits and positive living empowerment is critical.
引言
在全球范围内，暴露于人类免疫缺陷病毒（HIV）的婴儿（HEIs）在获得早期HIV诊断（EID）方面存在延迟。由于基森伊健康中心关于EID使用的数据匮乏，本研究评估了与HEIs（暴露于HIV的婴儿）使用EID相关的因素。
方法
这是一项对246对HIV阳性母婴进行的横断面研究。通过结构化问卷收集数据，双录入EpiData，并使用STATA在5%显著性水平下进行多项逻辑回归分析。
结果
132名（53.7%）HEIs未接受检测，60名（24.4%）在EID指南之外接受检测，54名（21.9%）按照指南进行检测。按照指南进行检测与母亲年龄超过30岁相关（调整后比值比[AOR]=2.75；95%置信区间[CI]：1.20 - 6.34；P=0.017）；在指南之外进行检测与母亲HIV血清学状态披露相关（AOR = 2.70；95% CI：1.10 - 6.63；P = 0.003）以及四次或更多次产前检查（ANC）就诊相关（AOR = 3.25；95% CI：1.23 - 8.59；P = 0.017）。然而，母亲对HIV传播的知晓与在指南之外进行检测相关（AOR = 2.90；95% CI：1.10 - 7.65；P = 0.032）以及按照指南进行检测相关（AOR = 3.70；95% CI：1.39 - 9.88；P = 0.009）。
结论
及时的EID检测率较低。在产前检查就诊期间提高母亲对EID的知晓以及增强积极生活的能力至关重要。
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