Department of Psychiatry Psychiatry Center of Chinese People's Liberation Army No.102 Hospital of People's Liberation Army Changzhou China.
DNA Laboratory Public Security Bureau of Changzhou Changzhou China.
Brain Behav. 2017 Oct 16;7(11):e00855. doi: 10.1002/brb3.855. eCollection 2017 Nov.
Men are more susceptible to impulsive behavior than women. Epidemiological studies revealed that the impulsive aggressive behavior is affected by genetic factors, and the male-specific Y chromosome plays an important role in this behavior. In this study, we investigated the association between the impulsive aggressive behavior and Y-chromosomal short tandem repeats (Y-STRs) loci.
The collected biologic samples from 271 offenders with impulsive aggressive behavior and 492 healthy individuals without impulsive aggressive behavior were amplified by PowerPlexY23 PCR System and the resultant products were separated by electrophoresis and further genotyped. Then, comparisons in allele and haplotype frequencies of the selected 22 Y-STRs were made in the two groups.
Our results showed that there were significant differences in allele frequencies at DYS448 and DYS456 between offenders and controls ( < .05). Univariate analysis further revealed significant frequency differences for alleles 18 and 22 at DYS448 (0.18 vs 0.27, compared to the controls, = .003, OR=0.57,95% CI=0.39-0.82; 0.03 vs 0.01, compared to the controls, = .003, OR=7.45, 95% CI=1.57-35.35, respectively) and for allele 17 at DYS456 (0.07 vs 0.14, compared to the controls, = .006, OR=0.48, 95% CI =0.28-0.82) between two groups. Interestingly, the frequency of haploid haplotype 22-15 on the DYS448-DYS456 (DYS448-DYS456-22-15) was significantly higher in offenders than in controls (0.033 vs 0.004, compared to the control, = .001, OR = 8.42, 95%CI =1.81-39.24). Moreover, there were no significant differences in allele frequencies of other Y-STRs loci between two groups. Furthermore, the unconditional logistic regression analysis confirmed that alleles 18 and 22 at DYS448 and allele 17 at DYS456 are associated with male impulsive aggression. However, the DYS448-DYS456-22-15 is less related to impulsive aggression.
Our results suggest a link between Y-chromosomal allele types and male impulsive aggression.
男性比女性更容易产生冲动行为。 流行病学研究表明，冲动攻击行为受遗传因素的影响，而男性特有的 Y 染色体在这种行为中起着重要作用。 在这项研究中，我们研究了冲动攻击行为与 Y 染色体短串联重复（Y-STR）位点之间的关联。
从 271 名具有冲动攻击行为的罪犯和 492 名无冲动攻击行为的健康个体中采集生物样本，使用 PowerPlexY23 PCR 系统进行扩增，并通过电泳分离产物，进一步对所选 22 个 Y-STR 的基因型进行分析。 然后，比较两组之间 22 个 Y-STR 等位基因和单倍型频率的差异。
我们的结果表明，在罪犯和对照组之间，DYS448 和 DYS456 上的等位基因频率存在显著差异（<0.05）。 单变量分析进一步显示，DYS448 上的等位基因 18 和 22 以及 DYS456 上的等位基因 17 的频率存在显著差异（与对照组相比，18 为 0.18 对 0.27，=0.003，OR=0.57，95%CI=0.39-0.82；0.03 对 0.01，=0.003，OR=7.45，95%CI=1.57-35.35）。 有趣的是，DYS448-DYS456 上的单倍型 22-15 的频率在罪犯中明显高于对照组（0.07 对 0.14，=0.006，OR=0.48，95%CI=0.28-0.82）。 此外，两组之间其他 Y-STR 位点的等位基因频率没有显著差异。 此外，无条件逻辑回归分析证实，DYS448 上的等位基因 18 和 22 以及 DYS456 上的等位基因 17 与男性冲动攻击有关。 然而，DYS448-DYS456-22-15 与冲动攻击的关系较小。
我们的结果表明 Y 染色体等位基因类型与男性冲动攻击之间存在联系。
