Yang Chun, Ba Huajie, Zhang Wei, Zhang Shuyou, Zhao Hanqing, Yu Haiying, Gao Zhiqin, Wang Binbin
Department of Psychiatry, Psychiatry Center of Chinese People's Liberation Army, No. 102 Hospital of People's Liberation Army, Changzhou 213003, Jiangsu Province, China.
DNA Laboratory, Public Security Bureau of Changzhou, Changzhou 213003, Jiangsu Province, China.
Gene. 2018 May 15;654:10-13. doi: 10.1016/j.gene.2018.02.039. Epub 2018 Feb 14.
Aggressive behavior represents an important public concern and a clinical challenge to behaviorists and psychiatrists. Aggression in humans is known to have an important genetic basis, so to investigate the association of Y chromosome short tandem repeat (Y-STR) loci with initiative-aggressive behavior, we compared allelic and haplotypic distributions of 22 Y-STRs in a group of Chinese males convicted of premeditated extremely violent crimes (n = 271) with a normal control group (n = 492). Allelic distributions of DYS533 and DYS437 loci differed significantly between the two groups (P < 0.05). The case group had higher frequencies of DYS533 allele 14, DYS437 allele 14, and haplotypes 11-14 of DYS533-DYS437 compared with the control group. Additionally, the DYS437 allele 15 frequency was significantly lower in cases than controls. No frequency differences were observed in the other 20 Y-STR loci between these two groups. Our results indicate a genetic role for Y-STR loci in the development of initiative aggression in non-psychiatric subjects.
攻击行为是一个重要的公共问题，对行为学家和精神科医生来说也是一项临床挑战。已知人类的攻击行为有重要的遗传基础，因此为了研究Y染色体短串联重复序列（Y-STR）基因座与主动性攻击行为的关联，我们比较了一组因有预谋的极端暴力犯罪而被定罪的中国男性（n = 271）和一个正常对照组（n = 492）中22个Y-STR的等位基因和单倍型分布。两组之间DYS533和DYS437基因座的等位基因分布存在显著差异（P < 0.05）。与对照组相比，病例组中DYS533等位基因14、DYS437等位基因14以及DYS533-DYS437单倍型11-14的频率更高。此外，病例组中DYS437等位基因15的频率显著低于对照组。在这两组之间的其他20个Y-STR基因座未观察到频率差异。我们的结果表明Y-STR基因座在非精神科受试者主动性攻击行为的发展中具有遗传作用。
