Islam Md Nasirul, Khan Mobin, Ahmad Nooruddin, Karim Md Fazal
Department of Hepatology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh.
The Liver Center, Dhaka, Bangladesh.
Euroasian J Hepatogastroenterol. 2016 Jan-Jun;6(1):10-12. doi: 10.5005/jp-journals-10018-1158. Epub 2016 Jul 9.
Cirrhosis of the liver is a common complication of chronic liver disease and is associated with portal hypertension and esophageal varices. In this study, we checked the implication of prothrombin time, if any, in the genesis of esophageal varices.
Sixty patients with cirrhosis of the liver were randomly assigned into two groups: Group I - 30 cirrhotic patients with esophageal varices, and group II - 30 cirrhotic patients without esophageal varices. The prothrombin time was checked for both groups.
A positive correlation was found between the prolonged plasma prothrombin time (> 4 seconds) and esophageal varices with a sensitivity of 56.67% and specificity of 73.33%. The Child-Pugh score showed a correlation; however, the size of varices did not exhibit any such relation.
Prothrombin time may be cautiously used to assess portal hypertension in a field level and rural setting where endoscopy is not available or feasible.
Islam MN, Khan M, Ahmad N, Al-Mahtab M, Karim MF. Plasma Prothrombin Time and Esophageal Varices in Patients with Cirrhosis of Liver. Euroasian J Hepato-Gastroenterol 2016;6(1):10-12.
肝硬化是慢性肝病的常见并发症，与门静脉高压和食管静脉曲张相关。在本研究中，我们探究了凝血酶原时间在食管静脉曲张发生过程中的作用（若有）。
60例肝硬化患者被随机分为两组：第一组——30例伴有食管静脉曲张的肝硬化患者，第二组——30例不伴有食管静脉曲张的肝硬化患者。对两组患者均检测凝血酶原时间。
血浆凝血酶原时间延长（>4秒）与食管静脉曲张之间存在正相关，敏感性为56.67%，特异性为73.33%。Child-Pugh评分显示出相关性；然而，静脉曲张的大小并未表现出任何此类关系。
在无法进行或不可行内镜检查的现场和农村环境中，凝血酶原时间可谨慎用于评估门静脉高压。
Islam MN, Khan M, Ahmad N, Al-Mahtab M, Karim MF. 肝硬化患者的血浆凝血酶原时间与食管静脉曲张。《欧亚肝脏胃肠病学杂志》2016；6(1):10 - 12。
