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日本丙型病毒性肝炎的过去、现在与未来

Past, Present, and Future of Viral Hepatitis C in Japan.

作者信息

Yatsuhashi Hiroshi

机构信息

Clinical Research Center, National Hospital Organization, Nagasaki Medical Center, Nagasaki, Japan.

出版信息

Euroasian J Hepatogastroenterol. 2016 Jan-Jun;6(1):49-51. doi: 10.5005/jp-journals-10018-1166. Epub 2016 Jul 9.

DOI:10.5005/jp-journals-10018-1166
PMID:29201725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5578559/
Abstract

UNLABELLED

Of all the industrialized countries of the world, Japan has the highest rate of hepatitis C. It also has 1 of the oldest and most varied histories of hepatitis C in the world among the industrialized modern nations. Hepatitis C and its complications are the leading cause of liver cancer in Japan. Japan has the highest rate of liver cancer among the industrialized countries. From 2004 to 2014, PegIFN/RBV treatment was the mainstream of hepatitis C treatment. In 2014, the first interferon-free therapy was approved in Japan. Subsequently, other interferon-free therapies have been approved. Hepatitis C virus disinfection in hepatitis C patients in Japan has become possible with a probability of 96% or more.

HOW TO CITE THIS ARTICLE

Yatsuhashi H. Past, Present, and Future of Viral Hepatitis C in Japan. Euroasian J Hepato-Gastroenterol 2016;6(1):49-51.

摘要

未标注

在世界所有工业化国家中,日本丙型肝炎发病率最高。在工业化现代国家中,日本也是世界上丙型肝炎历史最悠久、情况最多样化的国家之一。丙型肝炎及其并发症是日本肝癌的主要病因。日本在工业化国家中肝癌发病率最高。2004年至2014年期间,聚乙二醇干扰素/利巴韦林治疗是丙型肝炎治疗的主流方法。2014年,日本批准了首个无干扰素疗法。随后,其他无干扰素疗法也获得批准。日本丙型肝炎患者的丙型肝炎病毒消毒成功率达到96%或更高。

如何引用本文

八桥博。日本丙型病毒性肝炎的过去、现在和未来。《欧亚肝脏胃肠病学杂志》2016年;6(1):49 - 51。

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本文引用的文献

1
Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: an open-label, randomised, phase 3 trial.在未经治疗和先前经治的日本基因 1 型丙型肝炎患者中,使用利巴韦林联合或不联合利巴韦林的雷迪帕韦和索非布韦固定剂量复方制剂治疗 12 周:一项开放标签、随机、3 期临床试验。
Lancet Infect Dis. 2015 Jun;15(6):645-53. doi: 10.1016/S1473-3099(15)70099-X. Epub 2015 Apr 8.
2
Sofosbuvir plus ribavirin in Japanese patients with chronic genotype 2 HCV infection: an open-label, phase 3 trial.索磷布韦联合利巴韦林治疗日本慢性基因2型丙型肝炎病毒感染患者:一项开放标签的3期试验。
J Viral Hepat. 2014 Nov;21(11):762-8. doi: 10.1111/jvh.12312. Epub 2014 Sep 8.
3
Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection.达拉他韦联合阿舒瑞韦治疗慢性丙型肝炎1b型感染。
Hepatology. 2014 Jun;59(6):2083-91. doi: 10.1002/hep.27113. Epub 2014 Apr 1.
4
Molecular evolutionary analyses implicate injection treatment for schistosomiasis in the initial hepatitis C epidemics in Japan.分子进化分析表明,在日本最初的丙型肝炎流行中,血吸虫病注射治疗与之有关。
J Hepatol. 2005 Jan;42(1):47-53. doi: 10.1016/j.jhep.2004.09.023.