A Erdogan Mehmet, R Benli Ali, B Acmali Serap, Koroglu Mustafa, Atayan Yahya, Danalioglu Ahmet, Kayhan Burcak
Department of Gastroenterology, Karabük Education and Research Hospital, Karabük University, Karabük, Turkey.
Department of Family Medicine, Karabük University, Karabük, Turkey.
Euroasian J Hepatogastroenterol. 2017 Jan-Jun;7(1):6-10. doi: 10.5005/jp-journals-10018-1203. Epub 2017 May 5.
To investigate whether mean platelet volume (MPV) is a predictor of variceal bleeding in patients with cirrhotic portal hypertension.
This prospective cohort was performed in the internal medicine department of our tertiary care center. Cirrhotic patients were allocated into two groups: Group I consisted of 31 cases without a history of variceal bleeding, whereas group II was made up of 31 patients with a history of variceal bleeding. Data derived from medical history, physical examination, ultrasonography, gastrointestinal system endoscopy, complete blood count, hepatic, and renal function tests were recorded and compared between two groups. On physical examination, encephalopathy and ascites were evaluated and graded with respect to Child-Pugh-Turcotte classification.
There was no significant difference between the two groups in terms of age, duration of the disease, and gender of the patient. The only remarkable difference was that hemoglobin (p = 0.02) and hematocrit (p = 0.02) values were lower in group II. Neither the etiology of bleeding was different between groups nor did MPV seem to have a noteworthy impact on bleeding. Interestingly, risk of variceal bleeding increased in parallel to the higher grade of varices.
Our results imply that there is a correlation between the grade of varices and esophageal vari-ceal bleeding in cirrhotic patients. However, association between MPV and variceal bleeding could not be demonstrated. Utilization of noninvasive tests as predictors in these patients necessitates further controlled trials on larger series. Erdogan MA, Benli AR, Acmali SB, Koroglu M, Atayan Y, Danalioglu A, Kayhan B. Predictive Value of Mean Platelet Volume in Variceal Bleeding due to Cirrhotic Portal Hypertension. Euroasian J Hepato-Gastroenterol 2017;7(1):6-10.
探讨平均血小板体积（MPV）是否可作为肝硬化门静脉高压症患者静脉曲张出血的预测指标。
本前瞻性队列研究在我们三级医疗中心的内科进行。肝硬化患者被分为两组：第一组由31例无静脉曲张出血史的患者组成，而第二组由31例有静脉曲张出血史的患者组成。记录并比较两组患者从病史、体格检查、超声检查、胃肠系统内镜检查、全血细胞计数、肝功能和肾功能检查中获得的数据。体格检查时，根据Child-Pugh-Turcotte分类法对肝性脑病和腹水进行评估和分级。
两组患者在年龄、病程和性别方面无显著差异。唯一显著的差异是第二组患者的血红蛋白（p = 0.02）和血细胞比容（p = 0.02）值较低。两组间出血病因无差异，MPV似乎对出血也没有显著影响。有趣的是，静脉曲张出血风险随静脉曲张分级升高而增加。
我们的结果表明，肝硬化患者静脉曲张分级与食管静脉曲张出血之间存在相关性。然而，未能证实MPV与静脉曲张出血之间存在关联。在这些患者中使用非侵入性检查作为预测指标需要在更大系列的患者中进行进一步的对照试验。埃尔多安·马、本利·阿尔、阿克马利·斯布、科罗格鲁·米、阿塔扬·于、达纳利奥卢·阿、凯汉·巴。平均血小板体积在肝硬化门静脉高压所致静脉曲张出血中的预测价值。《欧亚肝脏胃肠病学杂志》2017年；7(1):6 - 10。
