Bolouki Moghaddam K, Zarkesh M, Kamali A, Dalili S, Heidarzadeh A, Hassanzadeh Rad A
Pediatric growth disorders research center, 17 shahrivar hospital, school of medicine, Guilan University of medical sciences, Rasht, Iran.
School of Medicine, Guilan University of Medical Sciences, Iran.
Iran J Ped Hematol Oncol. 2015;5(4):227-32. Epub 2015 Dec 10.
Interventricular hemorrhage (IVH) and Broncho pulmonary dysplasia(BPD) commonly occur in premature infants and they associate with platelet dysfunction. The aim of this study was to investigate the association of MPV and occurrence of IVH and BPD.
In this cross sectional study, 3 groups including IVH, BPD and control were compared. All participants were preterm neonates with <35 weeks of gestation. MPV was recorded during the first 48 hours of life for all cases. Data were reported by descriptive statistics and analyzed by Pearson correlation coefficient, spearman correlation coefficient, paired T test and multinomial regression analysis in SPSS version 17.
Higher MPV level was noted in BPD and IVH groups versus control group (9.79±0.73 fl and 10±1.04 fl versus 8.33±0,91 fl p<0.0001). Also, most participants in BPD (93.3%) and IVH (73.3%) groups had MPV >9 fl compared to controls (16.7%) (p<0.0001). Regression analysis showed that only MPV related to the occurrence of IVH (OR=2.200 95%CI p=0.013) and elevated MPV significantly increased duration of O2 therapy (p<0.0001) and mechanical ventilation (p=0.0010).
MPV value at first 48 hours of life can be noted as a simple biomarker for occurrence of BPD and specially IVH in preterm infants.
脑室内出血（IVH）和支气管肺发育不良（BPD）常见于早产儿，且与血小板功能障碍有关。本研究旨在探讨平均血小板体积（MPV）与IVH和BPD发生之间的关联。
在这项横断面研究中，比较了包括IVH组、BPD组和对照组在内的3组。所有参与者均为孕周<35周的早产儿。记录所有病例出生后48小时内的MPV。数据采用描述性统计进行报告，并在SPSS 17版中通过Pearson相关系数、Spearman相关系数、配对t检验和多项回归分析进行分析。
与对照组相比，BPD组和IVH组的MPV水平更高（分别为9.79±0.73 fl和10±1.04 fl，对照组为8.33±0.91 fl，p<0.0001）。此外，与对照组（16.7%）相比，BPD组（93.3%）和IVH组（73.3%）的大多数参与者MPV>9 fl（p<0.0001）。回归分析显示，只有MPV与IVH的发生相关（OR=2.200，95%CI，p=0.013），MPV升高显著增加了氧气治疗时间（p<0.0001）和机械通气时间（p=0.0010）。
出生后48小时内的MPV值可作为早产儿发生BPD尤其是IVH的一个简单生物标志物。
