测量胆碱能敏感性：I. 槟榔碱对双相情感障碍患者的影响。

Measuring cholinergic sensitivity: I. Arecoline effects in bipolar patients.

作者信息

Nurnberger J, Berrettini W, Mendelson W, Sack D, Gershon E S

机构信息

Clinical Neurogenetics Branch, Institute of Mental Health, Bethesda, MD.

出版信息

Biol Psychiatry. 1989 Mar 1;25(5):610-7. doi: 10.1016/0006-3223(89)90221-7.

DOI:10.1016/0006-3223(89)90221-7

PMID:2920194

Abstract

In a previous study, bipolar patients were found to be more sensitive than controls to induction of rapid eye movement (REM) sleep by the direct muscarinic agonist arecoline. We have replicated this observation in a new group of patients and controls. However, much overlap between groups was seen. Muscarinic supersensitivity appears to be present in some bipolar affective patients, but the REM induction procedure may not be the optimal method for measuring it.

摘要

在先前的一项研究中，发现双相情感障碍患者比对照组对直接毒蕈碱激动剂槟榔碱诱导的快速眼动（REM）睡眠更为敏感。我们在一组新的患者和对照组中重复了这一观察结果。然而，两组之间存在很大的重叠。毒蕈碱超敏反应似乎在一些双相情感障碍患者中存在，但REM诱导程序可能不是测量它的最佳方法。