Keshavan M, Dubé S, Grabowski J, Sitaram N
Department of Psychiatry, Wayne State University, Detroit, MI.
Psychiatry Res. 1988 Jun;24(3):333-6. doi: 10.1016/0165-1781(88)90113-8.
Serum thyroid hormones and the speed of rapid eye movement (REM) sleep induction by the central muscarinic agonist arecoline were measured in 21 normal volunteers. The arecoline-REM induction latencies had a modestly significant negative correlation with free thyroxine index. This finding is discussed in the light of observations in animal studies that thyroid hormones stimulate central cholinergic neuronal function.
在21名正常志愿者中测量了血清甲状腺激素以及中枢毒蕈碱激动剂槟榔碱诱导快速眼动（REM）睡眠的速度。槟榔碱诱导REM睡眠的潜伏期与游离甲状腺素指数呈中度显著负相关。根据动物研究中甲状腺激素刺激中枢胆碱能神经元功能的观察结果对这一发现进行了讨论。
