Keshavan M, Dubé S, Grabowski J, Sitaram N
Department of Psychiatry, Wayne State University, Detroit, MI.
Psychiatry Res. 1988 Jun;24(3):333-6. doi: 10.1016/0165-1781(88)90113-8.
Serum thyroid hormones and the speed of rapid eye movement (REM) sleep induction by the central muscarinic agonist arecoline were measured in 21 normal volunteers. The arecoline-REM induction latencies had a modestly significant negative correlation with free thyroxine index. This finding is discussed in the light of observations in animal studies that thyroid hormones stimulate central cholinergic neuronal function.