测量胆碱能敏感性：II. 槟榔碱对大鼠脑桥区域代谢活性的影响。

Measuring cholinergic sensitivity: II. Arecoline effects on metabolic activity in pontine regions of rat brain.

作者信息

Soncrant T T, Nurnberger J

机构信息

Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD.

出版信息

Biol Psychiatry. 1989 Mar 1;25(5):618-25. doi: 10.1016/0006-3223(89)90222-9.

DOI:10.1016/0006-3223(89)90222-9

PMID:2920195

Abstract

Brain imaging studies may help to localize areas particularly sensitive to cholinergic agonists. A study in rats using the 2-deoxyglucose method for studying changes in brain metabolic activity was performed. Among regions in the pons/medulla, arecoline, 0.05 mg/kg ip, increased glucose utilization in the dorsal raphe, median raphe, and basilar pontine nuclei without producing behavioral or cardiovascular effects. These brain areas, along with the hippocampus, may be pertinent to studies of muscarinic supersensitivity in humans.

摘要

脑成像研究可能有助于确定对胆碱能激动剂特别敏感的区域。利用2-脱氧葡萄糖法对大鼠进行了一项研究，以研究脑代谢活动的变化。在脑桥/延髓区域中，腹腔注射0.05mg/kg的槟榔碱可增加中缝背核、中缝正中核和脑桥基底部核团的葡萄糖利用率，且不产生行为或心血管效应。这些脑区以及海马体可能与人类毒蕈碱超敏反应的研究相关。