Mahdizadeh Fatemeh, Safari Saeed
Department of Emergency Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Department of Emergency Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Emerg (Tehran). 2017;5(1):e71. Epub 2017 Jun 21.
Warfarin induced skin necrosis (WISN) is a rare but important side effect of warfarin. Early diagnosis may lessen the amount of permanent tissue damage and can prevent progression to full thickness skin necrosis. So, physicians should be aware of such a complication. Screening for protein C or S or anti-thrombin deficiencies, or presence of anti-phospholipid antibodies before beginning warfarin therapy, could be helpful to avoid high levels of international normalized ratio (INR). Here, we report a 54-year-old man who presented to the emergency department with acral and penile gangrene following prolonged use of warfarin.
华法林所致皮肤坏死（WISN）是华法林一种罕见但重要的副作用。早期诊断可能会减少永久性组织损伤的程度，并可防止进展为全层皮肤坏死。因此，医生应意识到这种并发症。在开始华法林治疗前筛查蛋白C或S缺乏、抗凝血酶缺乏或抗磷脂抗体的存在，可能有助于避免国际标准化比值（INR）过高。在此，我们报告一名54岁男性，在长期使用华法林后因肢端和阴茎坏疽就诊于急诊科。
