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Extensive warfarin-induced skin necrosis successfully treated with negative pressure wound therapy.广泛华法林诱导的皮肤坏死经负压伤口治疗成功治愈。
BMJ Case Rep. 2014 Apr 17;2014:bcr2013203510. doi: 10.1136/bcr-2013-203510.
2
[Serious skin necrosis induced by warfarin].[华法林所致严重皮肤坏死]
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Warfarin-induced skin necrosis.华法林所致皮肤坏死。
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[Skin necrosis with oral anticoagulant].[口服抗凝剂导致的皮肤坏死]
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Skin Necrosis Induced by Coumarin Congeners.香豆素类同系物诱导的皮肤坏死
Tex Heart Inst J. 2017 Aug 1;44(4):233-236. doi: 10.14503/THIJ-17-6430. eCollection 2017 Aug.
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Warfarin skin necrosis associated with protein S deficiency and a mutation in the methylenetetrahydrofolate reductase gene.华法林所致皮肤坏死与蛋白S缺乏及亚甲基四氢叶酸还原酶基因突变相关。
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Warfarin-induced skin necrosis diagnosed on clinical grounds and treated with maggot debridement therapy.基于临床诊断的华法林所致皮肤坏死,并采用蛆虫清创疗法进行治疗。
BMJ Case Rep. 2013 Jan 28;2013:bcr2012007455. doi: 10.1136/bcr-2012-007455.
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Concurrent Hand and Penile Gangrene following Prolonged Warfarin Use; a Case Report.长期使用华法林后并发手部和阴茎坏疽;病例报告
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本文引用的文献

1
Warfarin-induced skin necrosis diagnosed on clinical grounds and treated with maggot debridement therapy.基于临床诊断的华法林所致皮肤坏死,并采用蛆虫清创疗法进行治疗。
BMJ Case Rep. 2013 Jan 28;2013:bcr2012007455. doi: 10.1136/bcr-2012-007455.
2
Mechanisms and clinical applications of the vacuum-assisted closure (VAC) Device: a review.真空辅助闭合(VAC)装置的机制及临床应用:综述
Am J Clin Dermatol. 2005;6(3):185-94. doi: 10.2165/00128071-200506030-00005.
3
Extensive tissue necrosis associated with warfarin sodium therapy.与华法林钠治疗相关的广泛组织坏死。
South Med J. 1980 Nov;73(11):1470-2. doi: 10.1097/00007611-198011000-00015.
4
Warfarin-induced skin necrosis: an entity occasionally requiring burn wound expertise.华法林所致皮肤坏死:一种偶尔需要烧伤创面专业知识的病症。
Burns Incl Therm Inj. 1988 Apr;14(2):139-41. doi: 10.1016/0305-4179(88)90220-3.
5
Coumarin necrosis of the penis.阴茎香豆素坏死
J Urol. 1989 Apr;141(4):946-8. doi: 10.1016/s0022-5347(17)41064-0.

广泛华法林诱导的皮肤坏死经负压伤口治疗成功治愈。

Extensive warfarin-induced skin necrosis successfully treated with negative pressure wound therapy.

作者信息

Murad Aizuri A, Daly Toddy, Mulligan Niall, Lenane Patsy

机构信息

Dermatology Department, Mater Misericordiae University Hospital, Dublin, Ireland.

出版信息

BMJ Case Rep. 2014 Apr 17;2014:bcr2013203510. doi: 10.1136/bcr-2013-203510.

DOI:10.1136/bcr-2013-203510
PMID:24744069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3992528/
Abstract

A 55-year-old woman presented with an extensive warfarin-induced skin necrosis while an inpatient for treatment of a pulmonary embolism and thromboembolic stroke. She had a background of diabetes mellitus, hypertension and dyslipidaemia. Her warfarin was stopped and she was anticoagulated with low-molecular weight heparin. The wound was successfully treated with a combination of antibiotic, debridement and negative pressure wound therapy.

摘要

一名55岁女性在住院治疗肺栓塞和血栓栓塞性中风时出现大面积华法林诱导的皮肤坏死。她有糖尿病、高血压和血脂异常病史。停用了她的华法林,并用低分子肝素进行抗凝治疗。通过联合使用抗生素、清创术和负压伤口治疗,伤口得到了成功治疗。