Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2017 Dec;96:936-943. doi: 10.1016/j.biopha.2017.11.149. Epub 2017 Dec 6.
Timely recognition of systemic bacterial infections in pediatric care setting is the basis for effective treatment and control. This review provides an overview of procalcitonin (PCT) as an early marker for the detection of severe, invasive bacterial infection in children. Almost all articles on biochemical property and clinical studies in PubMed and Scopus databases regarding their use in pediatric infections and the use of PCT as a marker of bacterial infections were examined. Various methods and analyzers are currently available for the evaluation of PCT. Employment of PCT in the identification of neonatal bacterial infection is a complex process in some conditions. Age specific cut-off, underlying syndrome, and maternal antibiotics usage should be considered when PCT is to be applied in neonates. PCT might be false-negative in these conditions. However, if used appropriately, it can lead to a higher specificity than other immunologic markers. Due to its correlation with the severity of infection, PCT can consequently be used as a prognostic indicator especially for sepsis and urinary tract infection. It is, therefore, a practical supplementary means for the identification of bacterial infections in pediatric health settings.
及时识别儿科医疗环境中的全身细菌感染是有效治疗和控制的基础。本综述介绍降钙素原 (PCT) 作为检测儿童严重侵袭性细菌感染的早期标志物。在 PubMed 和 Scopus 数据库中，几乎所有关于其在儿科感染中的应用以及 PCT 作为细菌感染标志物的应用的生化特性和临床研究的文章都进行了检查。目前有多种方法和分析仪可用于评估 PCT。在某些情况下，PCT 用于识别新生儿细菌感染是一个复杂的过程。在应用于新生儿时，应考虑年龄特异性截止值、潜在综合征和母亲使用抗生素的情况。在这些情况下，PCT 可能呈假阴性。但是，如果使用得当，它可以比其他免疫标志物具有更高的特异性。由于其与感染严重程度相关，PCT 因此可作为预后指标，特别是用于脓毒症和尿路感染。因此，它是儿科健康环境中识别细菌感染的一种实用的辅助手段。
