Wang Yujie, Liu Can, Fan Yinghan, Niu Chenyue, Huang Wanyun, Pan Yixuan, Li Jingze, Wang Yilin, Li Jun
College of Information Engineering, Sichuan Agricultural University, Ya'an, China.
Deep Vision Agriculture Lab, Sichuan Agricultural University, Ya'an, China.
Front Physiol. 2025 Mar 12;16:1512835. doi: 10.3389/fphys.2025.1512835. eCollection 2025.
Pneumonia is considered one of the most important causes of morbidity and mortality in the world. Bacterial and viral pneumonia share many similar clinical features, thus making diagnosis a challenging task. Traditional diagnostic method developments mainly rely on radiological imaging and require a certain degree of consulting clinical experience, which can be inefficient and inconsistent. Deep learning for the classification of pneumonia in multiple modalities, especially integrating multiple data, has not been well explored.
The study introduce the PneumoFusion-Net, a deep learning-based multimodal framework that incorporates CT images, clinical text, numerical lab test results, and radiology reports for improved diagnosis. In the experiments, a dataset of 10,095 pneumonia CT images was used-including associated clinical data-most of which was used for training and validation while keeping part of it for validation on a held-out test set. Five-fold cross-validation was considered in order to evaluate this model, calculating different metrics including accuracy and F1-Score.
PneumoFusion-Net, which achieved 98.96% classification accuracy with a 98% F1-score on the held-out test set, is highly effective in distinguishing bacterial from viral types of pneumonia. This has been highly beneficial for diagnosis, reducing misdiagnosis and further improving homogeneity across various data sets from multiple patients.
PneumoFusion-Net offers an effective and efficient approach to pneumonia classification by integrating diverse data sources, resulting in high diagnostic accuracy. Its potential for clinical integration could significantly reduce the burden of pneumonia diagnosis by providing radiologists and clinicians with a robust, automated diagnostic tool.
肺炎被认为是全球发病和死亡的最重要原因之一。细菌性肺炎和病毒性肺炎有许多相似的临床特征,因此诊断具有挑战性。传统诊断方法的发展主要依赖于放射影像学,并且需要一定程度的临床经验参考,这可能效率低下且不一致。针对多种模式下肺炎的分类,尤其是整合多种数据的深度学习尚未得到充分探索。
本研究引入了PneumoFusion-Net,这是一个基于深度学习的多模态框架,它整合了CT图像、临床文本、数值实验室检查结果和放射学报告以改进诊断。在实验中,使用了一个包含10095张肺炎CT图像的数据集(包括相关临床数据),其中大部分用于训练和验证,同时保留一部分用于在留出的测试集上进行验证。为了评估该模型,考虑了五折交叉验证,计算了包括准确率和F1分数在内的不同指标。
PneumoFusion-Net在留出的测试集上实现了98.96%的分类准确率和98%的F1分数,在区分细菌性肺炎和病毒性肺炎类型方面非常有效。这对诊断非常有益,减少了误诊,并进一步提高了来自多个患者的各种数据集之间的同质性。
PneumoFusion-Net通过整合多种数据源为肺炎分类提供了一种有效且高效的方法,从而实现了高诊断准确率。其临床整合潜力可以通过为放射科医生和临床医生提供一个强大的自动化诊断工具,显著减轻肺炎诊断的负担。