Alshaban Fouad A, Aldosari Mohammad, Ghazal Iman, Al-Shammari Hawraa, ElHag Saba, Thompson I Richard, Bruder Jennifer, Shaath Hibah, Al-Faraj Fatema, Tolefat Mohamed, Nasir Assal, Fombonne Eric
Qatar Biomedical Research Institute, Neurological Disorders Research Center, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha, Qatar.
Cleveland Clinic, Cleveland, OH, USA.
J Autism Dev Disord. 2025 Jun;55(6):1945-1952. doi: 10.1007/s10803-023-06137-w. Epub 2023 Sep 26.
Genetic and environmental risk factors associated with Autism Spectrum Disorders (ASD) continue to be a focus of research worldwide. Consanguinity, the cultural practice of marrying within a family, is common in cultures and societies of the Middle East, North Africa and parts of Asia. Consanguinity has been investigated as a risk factor for ASD in a limited number of studies, with mixed results. We employed registry and survey data from Qatar to evaluate the role of consanguinity as a risk factor for ASD.
Data were sourced from a national registry and a population-based survey of autism recently conducted in Qatar. We selected a sample of 891 children (mean age: 8.3 years) with (N = 361) or without (N = 530) ASD. Data on consanguinity and covariates were collected through questionnaires and interviews.
The prevalence of consanguinity in the overall sample was 41.2% with no significant difference between cases and controls (42.1% vs 41.3%; p = .836). In adjusted multiple logistic regression analyses, consanguinity was not associated with risk of ASD (aOR = 1.065; 95% CI: .751-1.509; NS).
Parental consanguinity was not associated with autism risk in our study. Replication in other populations with high rates of consanguineous unions is recommended.
与自闭症谱系障碍（ASD）相关的遗传和环境风险因素仍是全球研究的重点。近亲结婚，即在家族内部通婚的文化习俗，在中东、北非和亚洲部分地区的文化和社会中很常见。在少数研究中，近亲结婚已被作为ASD的一个风险因素进行调查，结果不一。我们利用卡塔尔的登记和调查数据来评估近亲结婚作为ASD风险因素的作用。
数据来自卡塔尔最近进行的一项全国登记和一项基于人群的自闭症调查。我们选取了891名儿童（平均年龄：8.3岁）作为样本，其中患有ASD的有361名，未患ASD的有530名。通过问卷调查和访谈收集近亲结婚及协变量的数据。
整个样本中近亲结婚的患病率为41.2%，病例组和对照组之间无显著差异（42.1%对41.3%；p = 0.836）。在调整后的多元逻辑回归分析中，近亲结婚与ASD风险无关（调整后的比值比 = 1.065；95%置信区间：0.751 - 1.509；无显著性差异）。
在我们的研究中，父母近亲结婚与自闭症风险无关。建议在其他近亲结婚率高的人群中进行重复研究。
