Szpecht Dawid, Gadzinowski Janusz, Nowak Irmina, Cygan Dorothy, Seremak-Mrozikiewicz Agnieszka, Kurzawińska Grażyna, Madajczak Dariusz, Drews Krzysztof, Szymankiewicz Marta
Chair and Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland.
Poznan University of Medical Sciences, Poznan, Poland.
Cent Eur J Immunol. 2017;42(3):287-293. doi: 10.5114/ceji.2017.67000. Epub 2017 Jun 8.
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects primarily preterm infants. Genetic factors are also taken into consideration in the pathogenesis of BPD. Genetic predispositions to higher production of inflammation mediators seem to be crucial.
The aim of this study was to evaluate the possible relationship between polymorphisms: interleukin-1β +3953 C>T, interleukin-6 -174 G>C and -596 G>A, tumour necrosis factor -308 G>A and interleukin-1RN VNTR 86bp and the occurrence of BPD in a population of 100 preterm infants born from singleton pregnancy, before 32+0 weeks of gestation, exposed to antenatal steroids therapy, and without congenital abnormalities.
In the study population BPD was diagnosed in 36 (36%) newborns. Among the studied polymorphisms we found the higher prevalence for BPD developing of the following genotypes: 1/2 (OR 1.842 [0.673-5.025] and 2/2 IL-1RN (OR 1.75 [0.418-6.908] 86bpVNTR; GC (2.222 [0.658-8.706]) and CC IL-6 -174G>C (1.6 [0.315-8.314]) and GA (2.753 [0.828-10.64]) and AA (1.5 [0.275-8.067] IL-6 -596G>A), GA 1.509 (0.515-4.301) TNF-α -308G>A. However, these finding were not statistically significant.
Genetic factors are undeniably involved in the pathogenesis of BPD. In the times of individualised therapy finding genes responsible for BPD might allow the development of new treatment strategies. A new way of specific therapy could ensure the reduction of complications connected with BPD and treatment costs.
支气管肺发育不良（BPD）是一种主要影响早产儿的慢性肺部疾病。BPD的发病机制中也考虑了遗传因素。炎症介质产生增加的遗传易感性似乎至关重要。
本研究的目的是评估白细胞介素-1β +3953 C>T、白细胞介素-6 -174 G>C和-596 G>A、肿瘤坏死因子-308 G>A以及白细胞介素-1受体拮抗剂可变数目串联重复序列86bp（IL-1RN VNTR 86bp）的多态性与100例单胎妊娠、孕32+0周前出生、接受产前类固醇治疗且无先天性异常的早产儿中BPD发生之间的可能关系。
在研究人群中，36例（36%）新生儿被诊断为BPD。在研究的多态性中，我们发现以下基因型发生BPD的患病率较高：1/2（比值比1.842 [0.673 - 5.025]）和2/2 IL-1RN 86bpVNTR（比值比1.75 [0.418 - 6.908]）；GC（2.222 [0.658 - 8.706]）和CC白细胞介素-6 -174G>C（1.6 [0.315 - 8.314]）以及GA（2.753 [0.828 - 10.64]）和AA（1.5 [0.275 - 8.067]）白细胞介素-6 -596G>A；GA 1.509（0.515 - 4.301）肿瘤坏死因子-α -308G>A。然而，这些发现无统计学意义。
遗传因素无疑参与了BPD的发病机制。在个体化治疗时代，找到导致BPD的基因可能有助于开发新的治疗策略。一种新的特异性治疗方法可以确保减少与BPD相关的并发症和治疗成本。
