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哪种环境因素与长期多发性硬化症发病率趋势相关：紫外线B辐射还是地磁干扰？

Which Environmental Factor Is Correlated with Long-Term Multiple Sclerosis Incidence Trends: Ultraviolet B Radiation or Geomagnetic Disturbances?

作者信息

Sajedi Seyed Aidin, Abdollahi Fahimeh

机构信息

Neuroscience Research Center, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

Department of Neurology, Sayyad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran.

出版信息

Mult Scler Int. 2017;2017:4960386. doi: 10.1155/2017/4960386. Epub 2017 Oct 24.

DOI:10.1155/2017/4960386
PMID:29204297
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5674510/
Abstract

BACKGROUND

Insufficient received ultraviolet B radiation (UV) is regarded as the main environmental risk factor (RF) for MS in vitamin D deficiency hypothesis. Nevertheless, geomagnetic disturbance (GMD) has also been proposed as a potential trigger for MS in GMD hypothesis. The aim of this study was to investigate which of these mentioned RF is correlated with long-term ultradecadal MS incidence.

METHODS

After a systematic search, long-term incidence reports of the United Kingdom (UK), Denmark, Tayside County, Nordland County, the Orkney, and Shetland Islands were selected for this retrospective time-series study. Possible lead-lag relationships between MS incidence, GMD, and UV were evaluated by cross-correlation analysis.

RESULTS

Significant positive correlations between GMD and MS incidence were seen in Tayside County (at lag of 2 years: = 0.38), Denmark (peak correlation at lag of 2 years: = 0.53), and UK (at lag of 1 year: = 0.50). We found a positive correlation between received UV and MS incidences in the Nordland at lag of 1 year ( = 0.49).

CONCLUSION

This study found significant positive correlations between alterations in GMD with alterations in long-term MS incidence in three out of six studied locations and supports the GMD hypothesis. The observed significant correlation between MS and UV is positive; hence it is not supportive for UV related vitamin D deficiency hypothesis.

摘要

背景

在维生素D缺乏假说中，紫外线B辐射（UV）接收不足被视为多发性硬化症（MS）的主要环境风险因素（RF）。然而，在地球磁扰动（GMD）假说中，GMD也被认为是MS的一个潜在触发因素。本研究的目的是调查上述哪种风险因素与长期年代际MS发病率相关。

方法

经过系统检索，选择了英国、丹麦、泰赛德郡、诺尔兰郡、奥克尼群岛和设得兰群岛的长期发病率报告进行这项回顾性时间序列研究。通过互相关分析评估MS发病率、GMD和UV之间可能的超前-滞后关系。

结果

在泰赛德郡（滞后2年： = 0.38）、丹麦（滞后2年时相关性峰值： = 0.53）和英国（滞后1年： = 0.50）观察到GMD与MS发病率之间存在显著正相关。我们发现诺尔兰郡在滞后1年时接收的UV与MS发病率之间存在正相关（ = 0.49）。

结论

本研究发现，在六个研究地点中的三个，GMD变化与长期MS发病率变化之间存在显著正相关，支持GMD假说。观察到的MS与UV之间的显著相关性为正；因此它不支持与UV相关的维生素D缺乏假说。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/15713b7c5a7a/MSI2017-4960386.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/c8e980f3f21a/MSI2017-4960386.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/eeb6d2b978be/MSI2017-4960386.002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/96df93e6b055/MSI2017-4960386.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/453f5e103e90/MSI2017-4960386.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/15713b7c5a7a/MSI2017-4960386.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/c8e980f3f21a/MSI2017-4960386.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/eeb6d2b978be/MSI2017-4960386.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/512ac9acaa92/MSI2017-4960386.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/b43571df37ae/MSI2017-4960386.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/279c26200ebd/MSI2017-4960386.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/96df93e6b055/MSI2017-4960386.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/453f5e103e90/MSI2017-4960386.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c67/5674510/15713b7c5a7a/MSI2017-4960386.008.jpg

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