非发作起始区：通向发作动态的一扇窗口。

Non ictal onset zone: A window to ictal dynamics.

作者信息

Afra Pegah, Hanrahan Sara J, Kellis Spencer Sterling, House Paul

机构信息

Department of Neurology, School of Medicine, University of Utah, Salt Lake City, UT, United States.

Colorado Neurological Institute, Englewood, CO, United States.

出版信息

Epilepsy Behav Case Rep. 2017 Oct 21;8:123-127. doi: 10.1016/j.ebcr.2017.10.003. eCollection 2017.

DOI:10.1016/j.ebcr.2017.10.003

PMID:29204348

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5707213/

Abstract

The focal and network concepts of epilepsy present different aspects of electroclinical phenomenon of seizures. Here, we present a 23-year-old man undergoing surgical evaluation with left fronto-temporal electrocorticography (ECoG) and microelectrode-array (MEA) in the middle temporal gyrus (MTG). We compare action-potential (AP) and local field potentials (LFP) recorded from MEA with ECoG. Seizure onset in the mesial-temporal lobe was characterized by changes in the pattern of AP-firing without clear changes in LFP or ECoG in MTG. This suggests simultaneous analysis of neuronal activity in differing spatial scales and frequency ranges provide complementary insights into how focal and network neurophysiological activity contribute to ictal activity.

摘要

癫痫的病灶和网络概念呈现了癫痫发作的电临床现象的不同方面。在此，我们介绍一名23岁男性，其正在接受手术评估，术中在左侧额颞叶进行了皮质脑电图（ECoG）监测，并在颞中回（MTG）植入了微电极阵列（MEA）。我们将MEA记录的动作电位（AP）和局部场电位（LFP）与ECoG进行了比较。内侧颞叶癫痫发作的特征是AP发放模式的改变，而MTG中的LFP或ECoG无明显变化。这表明，对不同空间尺度和频率范围内的神经元活动进行同步分析，可为病灶和网络神经生理活动如何导致发作活动提供互补性见解。