Department of Neurology, Columbia University, New York, NY 10032, USA.
J Clin Neurophysiol. 2010 Dec;27(6):406-11. doi: 10.1097/WNP.0b013e3181fdf8a1.
Microseizures are highly focal low-frequency epileptiform-appearing events recorded from the neocortex of epilepsy patients. Because of their tiny, often submillimeter distribution, they may be regarded as a high-resolution window into the epileptic process, providing an excellent opportunity to study the fine temporal structure of their origin and spread. A 16 mm² 96-microelectrode array with 400-μm interelectrode spacing was implanted in seven patients undergoing invasive EEG monitoring for medically refractory epilepsy. Seven microdischarge populations were tested for a substantial contribution by volume conduction to the observed waveform amplitudes. Single-unit activity was examined for specific evidence of neural activity at multiple sites within the microdischarge fields. We found that microdischarges appear to originate at a highly focal source location, likely within a single cortical macrocolumn, and spread to local and more distant sites via neural propagation.
微发作是从癫痫患者的大脑皮层记录到的高度局灶性低频癫痫样事件。由于其微小的、通常亚毫米级的分布，它们可以被视为癫痫过程的高分辨率窗口，为研究其起源和传播的精细时间结构提供了极好的机会。在接受侵入性 EEG 监测以治疗药物难治性癫痫的 7 名患者中，植入了一个 16 平方毫米的 96 微电极阵列，电极间距为 400 微米。对 7 个微放电群体进行了测试，以确定容积传导对观察到的波形幅度的大量贡献。对单个单元活动进行了检查，以在微放电场的多个部位发现特定的神经活动证据。我们发现微放电似乎起源于一个高度局灶性的源位置，可能在单个皮质大柱内，并通过神经传播传播到局部和更远的部位。
