Schevon Catherine A, Ng Sau K, Cappell Joshua, Goodman Robert R, McKhann Guy, Waziri Allen, Branner Almut, Sosunov Alexandre, Schroeder Charles E, Emerson Ronald G
Department of Neurology, Columbia University, New York, New York, USA.
J Clin Neurophysiol. 2008 Dec;25(6):321-30. doi: 10.1097/WNP.0b013e31818e8010.
The authors report the use of dense two-dimensional microelectrode array recordings to characterize fine resolution electrocortical activity ("microEEG") in epileptogenic human cortex. A 16-mm(2) 96 microelectrode array with 400-mum interelectrode spacing was implanted in five patients undergoing invasive EEG monitoring for medically refractory epilepsy. High spatial resolution data from the array were analyzed in conjunction with simultaneously acquired data from standard intracranial electrode grids and strips. microEEG recorded from within the epileptogenic zone demonstrates discharges resembling both interictal epileptiform activity ("microdischarges") and electrographic seizures ("microseizures") but confined to cortical regions as small as 200 microm(2). In two patients, this activity appeared to be involved in the initiation or propagation of electrographic seizures. The authors hypothesize that microdischarges and microseizures are generated by small cortical domains that form the substrate of epileptogenic cortex and play important roles in seizure initiation and propagation.
作者报告了使用密集二维微电极阵列记录来表征致痫性人类皮质中的高分辨率脑电活动（“微脑电图”）。一个16平方毫米、有96个微电极且电极间距为400微米的阵列被植入5名因药物难治性癫痫而接受侵入性脑电图监测的患者体内。来自该阵列的高空间分辨率数据与同时从标准颅内电极网格和条带获取的数据一起进行分析。从致痫区内记录的微脑电图显示出类似发作间期癫痫样活动（“微放电”）和脑电图发作（“微发作”）的放电，但局限于小至200平方微米的皮质区域。在两名患者中，这种活动似乎参与了脑电图发作的起始或传播。作者推测，微放电和微发作是由构成致痫性皮质底物的小皮质区域产生的，并且在癫痫发作的起始和传播中起重要作用。
