Seim Nolan B, Wright Chadwick L, Agrawal Amit
Department of Otolaryngology-Head and Neck Surgery, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Wexner Medical Center, 4000 Eye and Ear Institute, 915 Olentangy River Road, Columbus, OH, 43210, USA.
Wright Center of Innovation in Biomedical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, The Ohio State University Wexner Medical Center, 395 W, 12th Avenue, Rm. 430, Columbus, OH, 43210, USA.
World J Otorhinolaryngol Head Neck Surg. 2016 Jul 25;2(2):117-125. doi: 10.1016/j.wjorl.2016.05.008. eCollection 2016 Jun.
Sentinel lymph node biopsy has become a well-established and commonplace practice in many oncologic disease sites as a means to stage the regional lymphatics, avoid unnecessary surgery and decrease patient morbidity. In the head and neck, its role is well established for cutaneous melanoma with proven fidelity and survival benefit. Its role in use for other sites such as oral cavity carcinoma continues to develop with promising results from several recent trials. Although not widely adopted, the potential benefits of sentinel lymph node biopsy in the management of oral cavity carcinoma are apparent. Refinements in technology and protocols including development of novel radiopharmaceutical tracers, routine incorporation of detailed anatomic imaging, increasing surgeon experience and development of new intraoperative identification aids will likely lead to improvements in the use and accuracy of this technique.
前哨淋巴结活检已成为许多肿瘤疾病部位一种成熟且常见的做法，作为对区域淋巴管进行分期、避免不必要手术并降低患者发病率的手段。在头颈部，其在皮肤黑色素瘤中的作用已得到充分确立，具有可靠的准确性和生存获益。它在口腔癌等其他部位的应用作用仍在不断发展，最近的几项试验取得了令人鼓舞的结果。尽管未被广泛采用，但前哨淋巴结活检在口腔癌治疗中的潜在益处是显而易见的。技术和方案的改进，包括新型放射性药物示踪剂的开发、详细解剖成像的常规纳入、外科医生经验的增加以及新型术中识别辅助工具的开发，可能会提高该技术的应用和准确性。
