Liu Jeffrey C, Sopka Dennis S, Mehra Ranee, Lango Miriam N, Fundakowski Christopher, Ridge John A, Galloway Thomas J
Department of Otolaryngology, Temple University School of Medicine, Philadelphia PA, USA.
Head and Neck Surgery, Fox Chase Cancer Center, Philadelphia PA, USA.
World J Otorhinolaryngol Head Neck Surg. 2016 May 5;2(4):193-197. doi: 10.1016/j.wjorl.2016.03.001. eCollection 2016 Dec.
To report T1-2N0 tongue cancer recurrences initially treated with surgery alone.
Between 1990 and 2010, 27 patients at tertiary hospital referral center institution were treated with curative intent for locoregional recurrence after initial glossectomy with or without neck dissection for T1-2N0 tongue cancer. None had received adjuvant postoperative radiation as a component of the original treatment.
Median time to locoregional recurrence was 12 months (range 5-39 months) and 78% of failures occurred in the first 2 years. Most treatment failures were local (63%). Salvage strategy was risk-adapted by individual patient. The 5-year disease specific survival (DSS) was 61%. Patients with local recurrences alone fared significantly better than those with regional recurrences (5-yr DSS: 86% . 22%, = 0.0018). Local recurrences were usually treated by surgery alone, while regional recurrences were more commonly treated with combined modality treatment ( = 0.005).
Recurrence of early stage oral tongue cancer can be successfully salvaged in a majority of cases. Patients developing regional recurrence have significantly worse prognosis than those with local failures.
报告最初仅接受手术治疗的T1-2N0期舌癌复发情况。
1990年至2010年间，在一家三级医院转诊中心机构，27例T1-2N0期舌癌患者在初次舌切除术联合或不联合颈部清扫术后出现局部区域复发，接受了根治性治疗。所有患者在初始治疗时均未接受辅助性术后放疗。
局部区域复发的中位时间为12个月（范围5-39个月），78%的复发发生在头两年。大多数治疗失败为局部复发（63%）。挽救策略根据个体患者情况进行调整。5年疾病特异性生存率（DSS）为61%。单纯局部复发的患者预后明显好于区域复发的患者（5年DSS：86%对22%，P=0.0018）。局部复发通常仅通过手术治疗，而区域复发更常采用综合治疗（P=0.005）。
大多数早期口腔舌癌复发患者可成功挽救。出现区域复发的患者预后明显差于局部复发的患者。
