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脊髓干细胞及其微环境:室管膜作为干细胞龛。

Spinal Cord Stem Cells In Their Microenvironment: The Ependyma as a Stem Cell Niche.

机构信息

Neurofisiología Celular y Molecular, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.

Institute of Physiological Chemistry, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.

出版信息

Adv Exp Med Biol. 2017;1041:55-79. doi: 10.1007/978-3-319-69194-7_5.

DOI:10.1007/978-3-319-69194-7_5
PMID:29204829
Abstract

The ependyma of the spinal cord is currently proposed as a latent neural stem cell niche. This chapter discusses recent knowledge on the developmental origin and nature of the heterogeneous population of cells that compose this stem cell microenviroment, their diverse physiological properties and regulation. The chapter also reviews relevant data on the ependymal cells as a source of plasticity for spinal cord repair.

摘要

脊髓室管膜目前被认为是潜在的神经干细胞龛。本章讨论了有关构成这种干细胞微环境的异质性细胞群的发育起源和性质、它们的多种生理特性和调节的最新知识。本章还回顾了有关室管膜细胞作为脊髓修复来源的可塑性的相关数据。

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