Vaughan T R, Weber R W, Tipton W R, Nelson H S
Allergy-Immunology Service, Fitzsimons Army Medical Center, Aurora, CO.
Chest. 1989 Mar;95(3):558-62. doi: 10.1378/chest.95.3.558.
Measurements of FEV1 and PEFR performed on a Jones Pulmonor Spirometer (JPF) were compared with PEFR obtained with a mini-Wright peak flow meter (WPF) in 102 patients. Data were converted to percent predicted. Standard deviations of triplicate measurements were: FEV1, 3.01 percent; JPF, 7.22 percent; and WPF, 5.12 percent. Correlation of best of three measurements was FEV1-JPF r = .758; FEV1-WPF r = .744; and JPF-WPF r = .846. The mean percent predicted of the best of three values of FEV1 was 74.8 percent, JPF 91.4 percent, and WPF 94 percent. These higher values for percent predicted PEFR were obtained throughout the range of FEV1 values. Studies on nine normal volunteers in an atmospheric chamber suggested that higher altitudes may account for higher PEFR values. We conclude that PEFR, measured by either waterless spirometer or mini-Wright peak flow meter, has greater intrasubject variability than FEV1, and it tends to underestimate the degree of pulmonary impairment.
在102例患者中，将使用琼斯肺量计（JPF）测量的第一秒用力呼气容积（FEV1）和呼气峰值流速（PEFR）与使用小型赖特峰值流量计（WPF）测得的PEFR进行比较。数据换算为预测值百分比。三次重复测量的标准差分别为：FEV1为3.01%；JPF为7.22%；WPF为5.12%。三次测量中最佳值的相关性为：FEV1与JPF的r值为0.758；FEV1与WPF的r值为0.744；JPF与WPF的r值为0.846。FEV1三个最佳值的平均预测值百分比为74.8%，JPF为91.4%，WPF为94%。在整个FEV1值范围内，均获得了较高的预测值百分比的PEFR。在大气舱中对9名正常志愿者进行的研究表明，较高的海拔可能是PEFR值较高的原因。我们得出结论，无论是使用无水肺量计还是小型赖特峰值流量计测量的PEFR，其受试者内变异性均大于FEV1，并且它往往会低估肺损伤程度。
