Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Unidad Monterrey, Vía del Conocimiento 201 Parque PIIT, Apodaca, Nuevo León, 66600, Mexico.
Med Phys. 2018 Feb;45(2):703-713. doi: 10.1002/mp.12712. Epub 2017 Dec 21.
To demonstrate, via Monte Carlo simulation, that an image obtained from the patient-generated scattered radiation forced to impinge on the detector from a known direction by means of parallel-focused grids, can be used to complement the information conveyed by the primary image, such that accurate stereoscopic three-dimensional localization of fiducial markers can be achieved in a single kV x-ray exposure.
A voxelized Zubal phantom was used to model the process of fiducial marker localization. The markers were represented as made of gold and cylindrical in shape with dimensions of 5 mm in length and 1 mm in diameter. Three such markers were placed in the Zubal phantom at the prostate level. Two gantry-mounted image acquisition geometries were modeled: a single kV imaging system and a dual kV-MV imaging system. The detector was modeled as a 30 cm × 40 cm Gd O S screen with a thickness of 0.2 cm and a resolution of 768 × 1024 pixels. The PENELOPE Monte Carlo code was used to calculate the absorbed dose in this detector imparted by the transmitted primary and directional scatter radiation. A grayscale conversion was then applied to obtain an image from which the positions of the markers were determined. Two parallel-focused grid geometries were modeled, one based on the standard lead-carbon fiber grids and a proposed modification using tungsten as the shielding material. Absorbed dose in the patient model was also calculated.
It is shown that the combination of primary and directional scatter images provides the means for an accurate stereoscopic fiducial marker 3D localization in a single x-ray exposure, provided the antiscatter grids are made thick enough to allow radiation traveling only in a particular direction to reach the detector. For the proposed tungsten grid and the x-ray spectrum used in this work, grid ratios of 20 and thickness of 0.2 cm, provide the necessary shielding while for the standard lead grids, a ratio of at least 166 and a thickness of 2 cm are needed to obtain discernible directional scatter images.
We have shown that it is in principle possible to determine the 3D position of fiducial markers in a single exposure by making use of the radiation scattered by the patient to form an image that complements the information obtained with the primary beam. The method here proposed requires minimal modification of existing clinical hardware.
通过蒙特卡罗模拟证明,通过平行聚焦栅格迫使从已知方向入射到探测器上的患者产生的散射辐射所获得的图像,可以补充主图像所传达的信息,从而实现单个千伏 X 射线照射下的准确立体三维定位基准标记。
使用体素化的 Zubal 体模来模拟定位基准标记的过程。这些标记表示为金制的圆柱形,长度为 5 毫米,直径为 1 毫米。在 Zubal 体模中的前列腺水平放置了三个这样的标记。模拟了两种安装在旋转架上的图像采集几何形状:单千伏成像系统和双千伏-MV 成像系统。探测器建模为 30cm×40cm 的 Gd O S 屏幕,厚度为 0.2cm,分辨率为 768×1024 像素。使用 PENELOPE 蒙特卡罗代码计算了穿过的初级和定向散射辐射在该探测器中赋予的吸收剂量。然后应用灰度转换从该图像中确定标记的位置。模拟了两种平行聚焦栅格几何形状,一种基于标准的铅-碳纤维栅格,另一种使用钨作为屏蔽材料的改进型。还计算了患者模型中的吸收剂量。
结果表明,通过初级和定向散射图像的组合,可以在单次 X 射线照射下实现准确的立体基准标记 3D 定位,前提是抗散射栅格足够厚,以使仅沿特定方向传播的辐射到达探测器。对于所提出的钨栅格和本工作中使用的 X 射线光谱,栅格比为 20,厚度为 0.2cm,提供了必要的屏蔽,而对于标准的铅栅格,则需要栅格比至少为 166 和厚度为 2cm,才能获得可辨别的定向散射图像。
我们已经表明,通过利用散射辐射形成补充主射线束获得的信息的图像,可以在单次照射中确定基准标记的 3D 位置,原则上是可行的。所提出的方法需要对现有临床硬件进行最小的修改。