天然肽YY对清醒犬胰腺分泌和胆囊收缩素释放的影响。

Effect of natural peptide YY on pancreatic secretion and cholecystokinin release in conscious dogs.

作者信息

Hosotani R, Inoue K, Kogire M, Tatemoto K, Mutt V, Suzuki T, Rayford P L, Tobe T

机构信息

First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.

出版信息

Dig Dis Sci. 1989 Mar;34(3):468-73. doi: 10.1007/BF01536273.

DOI:10.1007/BF01536273

PMID:2920652

Abstract

The effects of natural peptide YY on pancreatic secretion under different stimulatory conditions and on fatty acid-induced cholecystokinin release were examined in five conscious dogs with pancreatic and gastric fistulas. Intravenous infusion of natural peptide YY at 1 and 0.2 microgram/kg/hr caused 60 and 40% inhibition of secretin- and cholecystokinin-stimulated secretion, respectively, and 40-50 and 20-40% inhibition of intraduodenal oleate stimulated secretion, respectively. A significant but transient decrease in the plasma cholecystokinin level was observed in response to peptide YY under oleate stimulation. The present study demonstrates that peptide YY has a potent inhibitory effect on both exogenously and endogenously stimulated pancreatic secretion and has a mild suppressive effect on fatty acid-induced cholecystokinin release suggesting that this peptide is an important colonic inhibitor of pancreatic secretion.

摘要

在五只患有胰瘘和胃瘘的清醒犬中，研究了天然肽YY在不同刺激条件下对胰腺分泌的影响以及对脂肪酸诱导的胆囊收缩素释放的影响。以1微克/千克/小时和0.2微克/千克/小时的剂量静脉输注天然肽YY，分别导致促胰液素和胆囊收缩素刺激的分泌受到60%和40%的抑制，十二指肠内油酸刺激的分泌分别受到40 - 50%和20 - 40%的抑制。在油酸刺激下，观察到血浆胆囊收缩素水平因肽YY而出现显著但短暂的下降。本研究表明，肽YY对外源性和内源性刺激的胰腺分泌均有强大的抑制作用，对脂肪酸诱导的胆囊收缩素释放有轻度抑制作用，提示该肽是胰腺分泌的重要结肠抑制剂。