肽YY（PYY）的分离与特性鉴定，肽YY是一种抑制胰腺外分泌的潜在肠道激素。
Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion.
作者信息
Tatemoto K
出版信息
Proc Natl Acad Sci U S A. 1982 Apr;79(8):2514-8. doi: 10.1073/pnas.79.8.2514.
Abstract
A new candidate hormone--designated peptide YY (PYY)--has been isolated from extracts of porcine upper intestinal tissue by using a novel chemical assay method. This peptide has been detected in the extracts by the presence of its unusual COOH-terminal tyrosine amide structure. The peptide consists of a linear chain of 36 amino acids and its complete amino acid sequence is: Tyr-Pro-Ala-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Ser-Arg-Tyr -Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2. This peptide has a distinct sequence homology to the pancreatic polypeptide. It is therefore proposed that PYY and the pancreatic polypeptide together form a new peptide family. PYY has been found to strongly inhibit both secretin- and cholecystokinin-stimulated pancreatic secretion in the anesthetized cat.
摘要
一种新的候选激素——命名为肽YY（PYY）——已通过一种新颖的化学检测方法从猪上肠道组织提取物中分离出来。通过其异常的羧基末端酪氨酸酰胺结构的存在，在提取物中检测到了这种肽。该肽由36个氨基酸的线性链组成，其完整的氨基酸序列为：Tyr-Pro-Ala-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Ser-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2。该肽与胰多肽具有明显的序列同源性。因此，有人提出PYY和胰多肽共同构成一个新的肽家族。已发现PYY能强烈抑制麻醉猫中促胰液素和胆囊收缩素刺激的胰腺分泌。
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