强行进入细胞核。
Forcing Entry into the Nucleus.
机构信息
King's College London, Guy's Campus, Centre for Stem Cells & Regenerative Medicine, 28th Floor, Tower Wing, Great Maze Pond, London SE1 9RT, UK; Institut Curie, PSL Research University, CNRS, UMR 144, 75005 Paris, France; Institut Pierre-Gilles de Gennes, PSL Research University, 75005 Paris, France.
Institut Curie, PSL Research University, CNRS, UMR 144, 75005 Paris, France; Institut Pierre-Gilles de Gennes, PSL Research University, 75005 Paris, France.
出版信息
Dev Cell. 2017 Dec 4;43(5):547-548. doi: 10.1016/j.devcel.2017.11.015.
Nuclear pore complexes tightly regulate nucleo-cytoplasmic transport, controlling the nuclear concentration of several transcription factors. In a recent issue of Cell, Elosegui-Artola et al. (2017) show that nuclear deformation modulates the nuclear entry rates of YAP/TAZ via nuclear pore stretching, clarifying how forces affect gene transcription.
核孔复合体严格调控核质转运，控制着几种转录因子在核内的浓度。在最近的一期《细胞》杂志上，Elosegui-Artola 等人（2017）表明，核变形通过核孔拉伸调节 YAP/TAZ 的核内进入速率，阐明了力如何影响基因转录。
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