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喹喔啉:近期药理学进展洞察

Quinoxaline: An insight into the recent pharmacological advances.

作者信息

Tariq Sana, Somakala K, Amir Mohd

机构信息

Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Hamdard University, New Delhi 110062, India.

Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Hamdard University, New Delhi 110062, India.

出版信息

Eur J Med Chem. 2018 Jan 1;143:542-557. doi: 10.1016/j.ejmech.2017.11.064. Epub 2017 Nov 24.

Abstract

Quinoxaline, a fused heterocycle of benzene and pyrazine rings has gained considerable attention in the field of contemporary medicinal chemistry. The moiety is of substantial importance because of its wide array of pharmacological activities viz. anti-cancer, antimalarial, anti-inflammatory, antimicrobial, anti-HIV etc. Diversely substituted quinoxalines are important therapeutic agents in the pharmaceutical industry. This review focusses on the quinoxaline derivatives developed during the last decennial period and their biomedical applications. A compilation of patents on quinoxaline is also included herein.

摘要

喹喔啉是苯环和吡嗪环稠合而成的杂环,在当代药物化学领域备受关注。由于其具有广泛的药理活性,如抗癌、抗疟疾、抗炎、抗菌、抗艾滋病毒等,该部分具有重要意义。不同取代的喹喔啉是制药行业重要的治疗剂。本综述聚焦于过去十年间开发的喹喔啉衍生物及其生物医学应用。本文还收录了喹喔啉相关专利的汇编。

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