Atrah H I, Davidson R J
Department of Haematology, Aberdeen Royal Infirmary, Foresterhill, Scotland.
Eur J Nucl Med. 1989;15(2):57-60. doi: 10.1007/BF00702619.
The results of all dual isotope tests (2142) carried out on 1989 patients, 807 males (40.6%) and 1182 females (59.4%), during a 10 year period (1976-1985 inclusive) in the Grampian Health Board Area (population 497,272) have been reviewed. Patient age ranged from 5-95 years with 45.5% over 60 years. The referring specialties were Gastroenterology (47.6%), Haematology (11.3%), Paediatrics (2.1%) and all others (39.0%). According to the manufacturer's recommended criteria, results were classified as normal in 1054 (49.2%), abnormal in 659 (30.8%), equivocal in 337 (15.7%) and unsatisfactory in 92 (4.3%) tests. Vitamin B12 malabsorption of ileal type was indicated in 544 tests (25.4%) and of gastric type in 115 (5.4%). Of the latter, 76 were related to pernicious anaemia, 10 to previous gastric surgery and 2 to gastric carcinoma. Of the 337 patients with equivocal results, 138 patients were reviewed and 115 (83.3%) found to have a documented cause for gastric malabsorption (96 pernicious anaemia and 19 previous gastric surgery). In 172 patients with proven pernicious anaemia the manufacturer's recommended criteria for gastric malabsorption were completely satisfied in only 76 (44.3%) but 167 (96.5%) had an excretion ratio greater than or equal to 1.3 and 127 (73.8%) a ratio greater than or equal to 1.7. Unsatisfactory tests were mainly due to incomplete urine collection (91.3%) or contamination with another isotope (5.4%).
对1989例患者（807例男性，占40.6%；1182例女性，占59.4%）在10年期间（1976年至1985年，含这两年）于格兰扁健康委员会区域（人口497,272）进行的所有双同位素检测（共2142项）结果进行了回顾。患者年龄范围为5至95岁，其中60岁以上者占45.5%。转诊科室为胃肠病学（47.6%）、血液学（11.3%）、儿科学（2.1%）以及其他所有科室（39.0%）。根据制造商推荐的标准，检测结果分类如下：正常1054项（49.2%），异常659项（30.8%），不确定337项（15.7%），不满意92项（4.3%）。544项检测（25.4%）提示存在回肠型维生素B12吸收不良，115项检测（5.4%）提示胃型维生素B12吸收不良。后者中，76例与恶性贫血有关，10例与既往胃部手术有关，2例与胃癌有关。在337例结果不确定的患者中，对138例患者进行了复查，发现115例（83.3%）有记录在案的胃吸收不良原因（96例为恶性贫血，19例为既往胃部手术）。在172例确诊为恶性贫血的患者中，仅76例（44.3%）完全符合制造商推荐的胃吸收不良标准，但167例（96.5%）排泄率大于或等于1.3，127例（73.8%）排泄率大于或等于1.7。不满意的检测主要是由于尿液收集不完整（91.3%）或受另一种同位素污染（5.4%）。
