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胶质母细胞瘤中传统与先进MRI、F-FDG PET/CT、表型与基因型的比较。

Comparison among conventional and advanced MRI, F-FDG PET/CT, phenotype and genotype in glioblastoma.

作者信息

Valentini Maria Consuelo, Mellai Marta, Annovazzi Laura, Melcarne Antonio, Denysenko Tetyana, Cassoni Paola, Casalone Cristina, Maurella Cristiana, Grifoni Silvia, Fania Piercarlo, Cistaro Angelina, Schiffer Davide

机构信息

Department of Neuroradiology, A.O.U. Città della Salute e della Scienza, 10126 Turin, Italy.

Research Center/Policlinico di Monza Foundation, 13100 Vercelli, Italy.

出版信息

Oncotarget. 2017 Oct 4;8(53):91636-91653. doi: 10.18632/oncotarget.21482. eCollection 2017 Oct 31.

DOI:10.18632/oncotarget.21482
PMID:29207673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5710953/
Abstract

Glioblastoma (GB) is a highly heterogeneous tumor. In order to identify the most malignant tumor areas, the extent of tumor infiltration and the sites giving origin to GB stem cells (GSCs), we combined positron emission tomography/computed tomography (PET/CT) and conventional and advanced magnetic resonance imaging (MRI) with histology, immunohistochemistry and molecular genetics. Prior to dura opening and tumor resection, forty-eight biopsy specimens [23 of contrast-enhancing (CE) and 25 of non-contrast enhancing (NE) regions] from 12 GB patients were obtained by a frameless image-guided stereotactic biopsy technique. The highest values of 2-[18F]-fluoro-2-deoxy-D-glucose maximum standardized uptake value (F-FDG SUV), relative cerebral blood volume (rCBV), Choline/Creatine (Cho/Cr), Choline/N-acetylaspartate (Cho/NAA) and Lipids/Lactate (LL) ratio have been observed in the CE region. They corresponded to the most malignant tumor phenotype, to the greatest molecular spectrum and stem cell potential. On the contrary, apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in the CE region were very variable. F-FDG SUV, Cho/Cr and Cho/NAA ratio resulted the most suitable parameters to detect tumor infiltration. In edematous areas, reactive astrocytes and microglia/macrophages were influencing variables. Combined MRI and F-FDG PET/CT allowed to recognize the specific biological significance of the different identified areas of GB.

摘要

胶质母细胞瘤（GB）是一种高度异质性肿瘤。为了确定最具恶性的肿瘤区域、肿瘤浸润范围以及GB干细胞（GSCs）的起源部位，我们将正电子发射断层扫描/计算机断层扫描（PET/CT）以及传统和先进的磁共振成像（MRI）与组织学、免疫组织化学和分子遗传学相结合。在打开硬脑膜并进行肿瘤切除之前，通过无框架图像引导立体定向活检技术从12例GB患者身上获取了48个活检标本[23个来自增强（CE）区域，25个来自非增强（NE）区域]。在CE区域观察到2-[18F]-氟-2-脱氧-D-葡萄糖最大标准化摄取值（F-FDG SUV）、相对脑血容量（rCBV）、胆碱/肌酸（Cho/Cr）、胆碱/N-乙酰天门冬氨酸（Cho/NAA）和脂质/乳酸（LL）比值的最高值。它们对应于最具恶性的肿瘤表型、最广泛的分子谱和干细胞潜能。相反，CE区域的表观扩散系数（ADC）和分数各向异性（FA）变化很大。F-FDG SUV、Cho/Cr和Cho/NAA比值是检测肿瘤浸润最合适的参数。在水肿区域，反应性星形胶质细胞和小胶质细胞/巨噬细胞是影响变量。联合MRI和F-FDG PET/CT能够识别GB不同确定区域的特定生物学意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0e9/5710953/edf986e52159/oncotarget-08-91636-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0e9/5710953/dbcc972b3172/oncotarget-08-91636-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0e9/5710953/c23d4ed795a1/oncotarget-08-91636-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0e9/5710953/c5d510bcade8/oncotarget-08-91636-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0e9/5710953/edf986e52159/oncotarget-08-91636-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0e9/5710953/dbcc972b3172/oncotarget-08-91636-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0e9/5710953/c23d4ed795a1/oncotarget-08-91636-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0e9/5710953/c5d510bcade8/oncotarget-08-91636-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0e9/5710953/edf986e52159/oncotarget-08-91636-g004.jpg

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