Department of Breast Surgery, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei, 230022, Anhui, PR China.
AMITA Health Saint Joseph Hospital Chicago, 2900 N. Lake Shore Drive, Chicago, IL 60657, USA.
Pathol Res Pract. 2019 Sep;215(9):152518. doi: 10.1016/j.prp.2019.152518. Epub 2019 Jun 28.
Caveolin-1 (CAV1) polymorphisms have been shown to correlated with breast cancer risk in previous studies. However, the role of CAV1 polymorphisms still remained indecisive, and dual functions of CAV1 was demonstrated in breast cancer development. Consequently, a meta-analysis to evaluate and summarize the association of the CAV1 polymorphisms with breast cancer susceptibility.
Extensive search was performed in PubMed, Web of Science, Google scholar, EMBASE.com, CNKI and Wanfang searching platform up to March 2019. The Newcastle-Ottawa Scale (NOS) were used to evaluate the quality of each study. The Odds ratios (ORs) and the 95% confidence intervals (CIs) were analyzed to evaluate the strength of the associations in five genetic models. Inter-study heterogeneity was quantified using the I-squared (I) test. In addition, the Egger's test and Begg's test were applied to evaluate the publication bias.
4 case-control studies with 2115 cases and 2138 controls were enrolled into this analysis. There was a significant association between rs3807987 polymorphism of CAV1 and breast cancer in allele comparison (A vs. G: OR = 1.288, 95％CI = 1.162-1.428, P < 0.001), heterozygote comparison (AG vs. GG: OR= 1.422, 95％CI=1.233-1.639, P < 0.001), and dominant comparison (AA+AG vs. GG: OR=1.395, 95％CI=1.228-1.586, P < 0.001). A significant association of rs3807987 polymorphism in allele comparison (A vs. G: OR=1.238, 95％CI=1.109-1.383, P < 0.001), heterozygote comparison (AG VS. GG: OR=1.466, 95％CI=1.267-1.697, P < 0.05), and dominant comparison (AA+AG vs. GG: OR=1.384, 95％CI=1.209-1.585, P < 0.001) was also founded amongst Chinese population. A significant association between rs7804372 polymorphism and breast cancer amongst Chinese population in recessive comparison (AA vs. AT + TT: OR = 0.730, 95％CI = 0.567-0.940, P = 0.015) was identified. No significant association between breast cancer risk and rs1997623 was found.
CAV1 rs3807987 and rs7804372 polymorphisms are associated with the change of breast cancer risk. More well-designed and large studies in various populations are needed to further elaborate these associations.
先前的研究表明，窖蛋白-1（CAV1）多态性与乳腺癌风险相关。然而，CAV1 多态性的作用仍不确定，并且 CAV1 具有双重功能，在乳腺癌的发展中起作用。因此，进行了荟萃分析以评估和总结 CAV1 多态性与乳腺癌易感性的关联。
在 PubMed、Web of Science、Google Scholar、EMBASE.com、CNKI 和万方检索平台上进行了广泛的搜索，截至 2019 年 3 月。使用纽卡斯尔-渥太华量表（NOS）评估每个研究的质量。使用五个遗传模型的优势比（ORs）和 95％置信区间（CIs）来评估关联的强度。使用 I 平方（I）检验量化研究间异质性。此外，还应用 Egger 检验和 Begg 检验评估发表偏倚。
共纳入了 4 项病例对照研究，共 2115 例病例和 2138 例对照。CAV1 的 rs3807987 多态性与乳腺癌在等位基因比较（A 对 G：OR=1.288，95％CI=1.162-1.428，P<0.001）、杂合子比较（AG 对 GG：OR=1.422，95％CI=1.233-1.639，P<0.001）和显性比较（AA+AG 对 GG：OR=1.395，95％CI=1.228-1.586，P<0.001）中存在显著相关性。rs3807987 多态性在等位基因比较（A 对 G：OR=1.238，95％CI=1.109-1.383，P<0.001）、杂合子比较（AG 对 GG：OR=1.466，95％CI=1.267-1.697，P<0.05）和显性比较（AA+AG 对 GG：OR=1.384，95％CI=1.209-1.585，P<0.001）中也存在显著相关性。在中国人群中，rs7804372 多态性与乳腺癌之间也存在显著相关性，在隐性比较中（AA 对 AT+TT：OR=0.730，95％CI=0.567-0.940，P=0.015）。rs1997623 与乳腺癌风险之间无显著关联。
CAV1 rs3807987 和 rs7804372 多态性与乳腺癌风险的变化有关。需要在不同人群中进行更多设计良好和大型的研究，以进一步阐明这些关联。
