Sarangi Rajlaxmi, Varadhan Nirupama, Bahinipati Jyotirmayee, Dhinakaran Asha, Ravichandran Kandasamy
Associate Professor, Department of Biochemistry, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Undergraduate Student, Pondichery Institute of Medical Sciences, Puducherry, India.
J Clin Diagn Res. 2017 Sep;11(9):BC09-BC13. doi: 10.7860/JCDR/2017/29300.10605. Epub 2017 Sep 1.
Airway inflammation and imbalance between oxidant/anti-oxidant mechanisms are postulated to play a major role in the pathogenesis and exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Previous studies on the role of serum Uric Acid (UA) in COPD subjects have been both confounding and inconclusive.
To measure the serum UA levels among COPD subjects and to correlate with different stages of the disease.
The study included 39 stable COPD subjects (21 males, 18 females; 13 smokers, 26 nonsmokers; age group; 40 to 60 years) and compared with 46 control subjects from the general population. Serum UA levels were measured by enzymatic colorimetric assay in fully automated analyser (Cobas Integra 400+, Roche, Germany) using commercially available kits from Roche. This was further correlated with duration and severity of COPD {determined as per Global Initiative for Obstructive Lung Disease (GOLD) criteria}.
The mean age of COPD and control subjects was 62.97±11.30 and 48.76±12.71 years, respectively (p<0.001). COPD cases had significantly higher level of UA compared to control subjects (4.85±1.67 vs. 2.32±0.93 mg/dl, respectively, p<0.001). Female subjects with COPD had higher levels of UA compared to their male counterparts (5.15±1.89 vs. 4.59±1.45 mg/dl, respectively, p=0.3). Similar insignificant (p=0.56) trend was also observed among control subjects. Hyperuricaemia correlated significantly (p< 0.05) with advance duration (≥ 10 years) of COPD; whereas, statistically insignificant trend was observed for GOLD stage 3/4 versus stage 1/2 disease. Nonsmokers were having higher uric acid level than smokers. Alcohol intake did not affect the level of uric acid in COPD cases (p=0.79).
Serum uric acid is a simple, cost effective biochemical test which may be useful in risk stratification of subjects with newly diagnosed chronic obstructive pulmonary disease. Hyperuricaemia is associated with advance duration and stage of COPD.
气道炎症以及氧化/抗氧化机制失衡被认为在慢性阻塞性肺疾病（COPD）的发病机制和病情加重过程中起主要作用。先前关于血清尿酸（UA）在COPD患者中作用的研究结果相互矛盾且尚无定论。
测定COPD患者的血清UA水平，并将其与疾病的不同阶段相关联。
该研究纳入了39例稳定期COPD患者（21例男性，18例女性；13例吸烟者，26例非吸烟者；年龄在40至60岁之间），并与46例来自普通人群的对照者进行比较。使用罗氏公司的市售试剂盒，通过全自动分析仪（德国罗氏Cobas Integra 400+）中的酶比色法测定血清UA水平。进一步将其与COPD的病程和严重程度相关联（根据慢性阻塞性肺疾病全球倡议组织（GOLD）标准确定）。
COPD患者和对照者的平均年龄分别为62.97±11.30岁和48.76±12.71岁（p<0.001）。与对照者相比，COPD患者的UA水平显著更高（分别为4.85±1.67mg/dl和 2.32±0.93mg/dl，p<0.001）。COPD女性患者的UA水平高于男性患者（分别为5.15±1.89mg/dl和4.59±1.45mg/dl，p=0.3）。在对照者中也观察到类似的无显著差异（p=0.56）的趋势。高尿酸血症与COPD的病程延长（≥10年）显著相关（p<0.05）；然而，对于GOLD 3/4期与1/2期疾病，观察到的趋势无统计学意义。非吸烟者的尿酸水平高于吸烟者。饮酒对COPD患者尿酸水平无影响（p=0.79）。
血清尿酸是一种简单、经济有效的生化检测方法，可能有助于对新诊断的慢性阻塞性肺疾病患者进行风险分层。高尿酸血症与COPD的病程延长和疾病分期相关。
