Department of Radiology, Ningbo First Hospital, Ningbo, China.
Department of Radiology, Jimo Traditional Chinese Medicine Hospital, Qingdao, China.
Biosci Rep. 2018 Jan 10;38(1). doi: 10.1042/BSR20170977. Print 2018 Feb 28.
Aim To investigate the feasibility of low-concentration contrast (270 mg/ml) together with low tube voltage (80 kV) and adaptive iterative dose reduction (AIDR)-3D reconstruction in liver computed tomography (CT) perfusion imaging.Method A total of 15 healthy New Zealand rabbits received two CT scans each. The first scan (control) was acquired at 100 kV and 100 mA with iopromide (370 mg/ml), while the second scan (experimental) was acquired at 80 kV and 100 mA with iodixanol (270 mg/ml) 24 h after the first scan. The obtained images were reconstructed with filtered back projection (FBP) and AIDR-3D in the control and experimental groups respectively. The perfusion parameters (hepatic artery perfusion [HAP], portal vein perfusion [PVP], hepatic perfusion index [HPI], and total liver perfusion [TLP]) and image quality (image quality score, average CT value of abdomen aorta, signal-to-noise ratio [SNR], contrast-to-noise ratio [CNR], and figure of merit [FOM]) were compared using a paired -test or Mann-Whitney test between the two groups, when appropriate. The effective radiation dose and iodine intake were also recorded and compared.Results With the exception of the FOM criteria, the image quality and perfusion parameters were not significantly different between the two groups. The effective radiation dose and iodine intake were 38.79% and 27.03% lower respectively, in the experimental group.Conclusion Low-concentration contrast (iodixanol, 270 mg/ml) together with low tube voltage (80 kV) and AIDR-3D reconstruction help to reduce radiation dose and iodine intake without compromising perfusion parameters and image quality in liver CT perfusion imaging.
目的 探讨低浓度对比剂（270mg/ml）联合低管电压（80kV）和自适应迭代剂量降低（AIDR）-3D 重建在肝脏 CT 灌注成像中的可行性。
方法 共 15 只新西兰大白兔接受了两次 CT 扫描，第一次扫描（对照组）采用 100kV 和 100mA 注射碘普罗胺（370mg/ml），第二次扫描（实验组）采用 80kV 和 100mA 注射碘昔醇（270mg/ml），两次扫描间隔 24 小时。分别采用滤波反投影（FBP）和 AIDR-3D 对两组图像进行重建。使用配对 t 检验或 Mann-Whitney U 检验比较两组间的灌注参数（肝动脉灌注量[HAP]、门静脉灌注量[PVP]、肝灌注指数[HPI]和全肝灌注量[TLP]）和图像质量（图像质量评分、腹部主动脉平均 CT 值、信噪比[SNR]、对比噪声比[CNR]和调制传递函数[MTF]），适当情况下。还记录并比较了有效辐射剂量和碘摄入量。
结果 除 MTF 标准外，两组间图像质量和灌注参数无显著差异。实验组的有效辐射剂量和碘摄入量分别降低了 38.79%和 27.03%。
结论 低浓度对比剂（碘昔醇，270mg/ml）联合低管电压（80kV）和 AIDR-3D 重建有助于降低辐射剂量和碘摄入量，同时不影响肝脏 CT 灌注成像的灌注参数和图像质量。
