The Hospital of Obstetrics & Gynaecology, Fudan University, Shanghai, China.
Department of Obstetrics & Gynaecology, The University of Auckland, Auckland, New Zealand.
Sci Rep. 2017 Dec 5;7(1):16922. doi: 10.1038/s41598-017-17265-6.
The estrogen (ER) or progesterone receptors (PR) is positively associated with better clinical outcomes in ovarian cancer. Whether metastasis or recurrence of ovarian cancer is correlated with this association has not been investigated. Data on 894 women with epithelial ovarian cancer were collected and the association between ER or PR positivity and peritoneal or lymph node metastases or recurrence was analysed. ER or PR positivity was higher in high-grade, low-grade serous and endometrioid carcinoma, but lower in mucinous and clear-cell carcinoma. Significantly higher ER or PR positivity was seen in endometrioid carcinoma or high-grade serous carcinoma with peritoneal metastases, respectively, but not other subtypes. In addition, there was no significant difference in ER or PR positivity between cases with and without lymph node metastasis in these five subtypes. In recurrent high-grade serous carcinoma with peritoneal metastases (n = 103), the positivity of ER or PR was 86% and 55% respectively. Our data demonstrate that the association between ER or PR positivity and peritoneal metastases was only seen in endometrioid or high grade serous carcinoma, respectively. There was no association of ER or PR positivity and lymph node metastases. The majority of recurrent high-grade serous carcinoma with peritoneal metastases (86%) were ER positive.
雌激素（ER）或孕激素受体（PR）与卵巢癌的临床预后较好相关。但是否与卵巢癌的转移或复发相关尚未被研究。收集了 894 名上皮性卵巢癌患者的数据，分析了 ER 或 PR 阳性与腹膜或淋巴结转移或复发之间的关系。高级别、低级别浆液性和子宫内膜样癌的 ER 或 PR 阳性率较高，但黏液性和透明细胞癌的 ER 或 PR 阳性率较低。腹膜转移的子宫内膜样癌或高级别浆液性癌的 ER 或 PR 阳性率显著更高，但其他亚型则没有。此外，在这五种亚型中，淋巴结转移的病例与无淋巴结转移的病例之间的 ER 或 PR 阳性率没有差异。在有腹膜转移的复发性高级别浆液性癌（n=103）中，ER 或 PR 的阳性率分别为 86%和 55%。我们的数据表明，ER 或 PR 阳性与腹膜转移的相关性仅见于子宫内膜样癌或高级别浆液性癌，与淋巴结转移无关。大多数有腹膜转移的复发性高级别浆液性癌（86%）为 ER 阳性。
