Qusairy Zahraa, Gangloff Anne, Leung Shuk On Annie
Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
CHU de Québec-Université Laval Research Center, Québec City, QC G1V 4G2, Canada.
Curr Oncol. 2023 Sep 13;30(9):8386-8400. doi: 10.3390/curroncol30090609.
Cholesterol plays an essential role in maintaining the rigidity of cell membranes and signal transduction. Various investigations confirmed empirically that the dysregulation of cholesterol homeostasis positively correlates with tumor progression. More specifically, recent studies suggested the distinct role of cholesterol in ovarian cancer cell proliferation, metastasis and chemoresistance. In this review, we summarize the current findings that suggest the contribution of cholesterol homeostasis dysregulation to ovarian cancer progression and resistance to anti-cancer agents. We also discuss the therapeutic implications of cholesterol-lowering drugs in ovarian cancer.
胆固醇在维持细胞膜的刚性和信号转导中起着至关重要的作用。各种研究通过实验证实，胆固醇稳态失调与肿瘤进展呈正相关。更具体地说，最近的研究表明胆固醇在卵巢癌细胞增殖、转移和化疗耐药性中具有独特作用。在这篇综述中，我们总结了目前的研究结果，这些结果表明胆固醇稳态失调对卵巢癌进展和抗癌药物耐药性的影响。我们还讨论了降低胆固醇药物在卵巢癌治疗中的意义。
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