Kitazawa Y, Sugiyama K, Taniguchi T
Department of Ophthalmology, Gifu University School of Medicine, Japan.
Graefes Arch Clin Exp Ophthalmol. 1989;227(1):13-6. doi: 10.1007/BF02169817.
We evaluated the ability of topical clonidine to suppress an acute rise in postoperative intraocular pressure (IOP) following Nd:YAG laser iridotomy. A total of 36 eyes (29 patients) with chronic primary angle-closure glaucoma underwent Q-switched Nd:YAG laser iridotomy: 18 eyes were treated topically with 0.5% clonidine ophthalmic solution prior to and immediately following the procedure, and a control group of 18 eyes underwent Nd:YAG laser iridotomy without topical clonidine. The control group was selected to match the clonidine-treated group in terms of preoperative IOP, the extent of peripheral anterior synechia, and the total amount of laser energy delivered. None of the clonidine-treated eyes experienced an IOP rise greater than 4 mm Hg over baseline, whereas 4 of the nontreated eyes (22.2%) developed an IOP rise greater than 10 mm Hg. The mean IOPs were significantly lower during the first 4 h postsurgery in the clonidine-treated eyes.
钇铝石榴石激光虹膜切开术后眼内压（IOP）急性升高的能力。共有36只眼（29例患者）患有慢性原发性闭角型青光眼，接受了调Q钕:钇铝石榴石激光虹膜切开术：18只眼在手术前及术后立即局部使用0.5%可乐定眼药水治疗，18只眼的对照组在未局部使用可乐定的情况下接受钕:钇铝石榴石激光虹膜切开术。对照组在术前眼压、周边前粘连程度和激光总能量方面与可乐定治疗组相匹配。可乐定治疗组中没有一只眼的眼压升高超过基线4 mmHg，而未治疗的眼中有4只（22.2%）眼压升高超过10 mmHg。可乐定治疗组术后头4小时的平均眼压显著较低。
