Chen Shixuan, Boda Sunil Kumar, Batra Surinder K, Li Xiaoran, Xie Jingwei
Department of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Adv Healthc Mater. 2018 Mar;7(6):e1701024. doi: 10.1002/adhm.201701024. Epub 2017 Dec 6.
This article reviews the recent progress of electrospun nanofibers in cancer research. It begins with a brief introduction to the emerging potential of electrospun nanofibers in cancer research. Next, a number of recent advances on the important features of electrospun nanofibers critical for cancer research are discussed including the incorporation of drugs, control of release kinetics, orientation and alignment of nanofibers, and the fabrication of 3D nanofiber scaffolds. This article further highlights the applications of electrospun nanofibers in several areas of cancer research including local chemotherapy, combinatorial therapy, cancer detection, cancer cell capture, regulation of cancer cell behavior, construction of in vitro 3D cancer model, and engineering of bone microenvironment for cancer metastasis. This progress report concludes with remarks on the challenges and future directions for design, fabrication, and application of electrospun nanofibers in cancer diagnostics and therapeutics.
本文综述了电纺纳米纤维在癌症研究中的最新进展。文章首先简要介绍了电纺纳米纤维在癌症研究中展现出的潜在应用价值。接下来，讨论了电纺纳米纤维对癌症研究至关重要的一些重要特性方面的多项最新进展，包括药物的掺入、释放动力学的控制、纳米纤维的取向和排列，以及三维纳米纤维支架的制造。本文进一步强调了电纺纳米纤维在癌症研究的几个领域中的应用，包括局部化疗、联合治疗、癌症检测、癌细胞捕获、癌细胞行为调控、体外三维癌症模型构建，以及用于癌症转移的骨微环境工程。本进展报告最后对电纺纳米纤维在癌症诊断和治疗中的设计、制造及应用所面临的挑战和未来方向进行了评述。
